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Diflorasone

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Identification
Molecular formula
C25H32F2O6
CAS number
2557-49-5
IUPAC name
[17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
State
State

At room temperature, diflorasone is a crystalline solid. When formulated into pharmaceutical creams or ointments, it becomes a part of a semi-solid emulsion or suspension designed for topical application to the skin.

Melting point (Celsius)
238.50
Melting point (Kelvin)
511.65
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
494.53g/mol
Molar mass
494.5400g/mol
Density
0.9837g/cm3
Appearence

Diflorasone is typically available as a white to off-white crystalline powder in its pure form. It is generally formulated into creams or ointments for topical use, which are smooth and creamy in appearance. These topical formulations are applied to the skin to reduce inflammation and alleviate symptoms of dermatological conditions.

Comment on solubility

Solubility of 17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl butanoate

The solubility of the compound with the formula C25H32F2O6 presents interesting characteristics due to its complex structure. This compound can be classified based on its solubility in different solvents, which can greatly affect its behavior in chemical processes. Here are some key points regarding its solubility:

  • Polar Solvents: Compounds containing hydroxyl (-OH) and acetoxy (-OCOCH3) groups usually show increased solubility in polar solvents such as water and alcohols.
  • Non-Polar Solvents: The presence of hydrophobic carbon chains and fluorine atoms suggests that this compound may also exhibit reasonable solubility in non-polar solvents like hexane or toluene.
  • Temperature Dependence: As with many organic compounds, solubility may vary with temperature, generally increasing in higher temperatures.
  • Chemical Stability: The stability of solubility depends on the chemical context, as interactions with other solutes can lead to precipitation or complex formation.

In summary, one might expect the solubility characteristics of this compound to be an intriguing study, exemplifying the delicate balance between polar and non-polar interactions. As stated in solubility theories, *“Like dissolves like,”* making it essential to consider the solvent's polarity for effective dissolution.

Interesting facts

Interesting Facts about 17-(2-acetoxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl butanoate

This intriguing compound features a complex structure that captures the interest of chemists due to its diverse functional groups and biological activity. Here are some compelling insights:

  • Structural Complexity: The compound integrates a unique octahydrocyclopenta[a]phenanthrene core, which is a fused polycyclic structure. This complexity often implies potential for varied interactions in biological systems.
  • Fluorinated Features: The presence of difluoro groups likely enhances the compound's lipophilicity, making it more effective in penetrating biological membranes. Fluorinated compounds are known for their altered reactivity and affinity, leading to interesting pharmacological properties.
  • Biological Potential: With its hydroxy and acetoxyacyl functional groups, this compound may exhibit significant hormonal or antitumoral activities, suggesting potential applications in the field of medicinal chemistry.
  • Drug Design Implications: The incorporation of multiple functional groups and fluorine atoms in a single molecule makes it a candidate for drug design, where optimizing bioactivity while minimizing toxicity is vital.

As scientist Linus Pauling famously stated, “Science is not static. It is the process of exploration and change.” The exploration of such compounds opens avenues for innovative drug development and enhances our understanding of chemical interactions in biological systems. This particular compound serves as a reminder of the intricate balance between structure and function in the world of chemistry.

Understanding the synthesis and reactivity of compounds like this one not only enriches our knowledge but also exemplifies the exciting intersections of organic chemistry and pharmacology.

Synonyms
SCHEMBL4581
DTXSID40860307
21-(acetyloxy)-6,9-difluoro-11-hydroxy-3,20-dioxopregna-1,4-dien-17-yl butanoate