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Fluticasone propionate

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Identification
Molecular formula
C25H31F3O5S
CAS number
80474-14-2
IUPAC name
[17-[3-(1-isopropyl-2-methyl-cyclopropyl)-1-methyl-propyl]-10,13,14-trimethyl-2,3-disulfooxy-1,2,3,4,5,6,7,8,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-6-yl] hydrogen sulfate
State
State

At room temperature, fluticasone propionate is in a solid state. It is stable and retains its form when stored under appropriate conditions, typically at room temperature in a well-closed container, protected from light and moisture.

Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
328.50
Boiling point (Kelvin)
601.65
General information
Molecular weight
500.59g/mol
Molar mass
500.5860g/mol
Density
1.4455g/cm3
Appearence

Fluticasone propionate typically appears as a white to off-white powder. It is crystalline and odorless or almost odorless, offering a fine particulate appearance that is common among pharmaceutical corticosteroids.

Comment on solubility

Solubility of 17-[3-(1-isopropyl-2-methyl-cyclopropyl)-1-methyl-propyl]-10,13,14-trimethyl-2,3-disulfooxy-1,2,3,4,5,6,7,8,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-6-yl hydrogen sulfate

The solubility of the compound C25H31F3O5S, is influenced by several factors such as its chemical structure, polarity, and the presence of functional groups. Here are some crucial points to consider regarding its solubility:

  • Polarity: The presence of sulfooxy groups enhances the polar characteristics of this compound, which suggests it may be more soluble in polar solvents.
  • Hydrogen bonding: The hydrogen sulfate moiety can form hydrogen bonds with solvent molecules, which could improve solubility.
  • Hydrophobic regions: The extensive hydrophobic parts of the compound may lead to reduced solubility in water.

Overall, the solubility can be quite variable, depending on the solvent used. It is likely to exhibit:

  • High solubility: In polar aprotic solvents like dimethyl sulfoxide (DMSO) or alcohols.
  • Low solubility: In nonpolar solvents due to its complex hydrophobic structure.

In conclusion, understanding the balance between polar and nonpolar characteristics is essential for predicting the solubility of this intriguing compound in various solvents.

Interesting facts

Interesting Facts about the Compound

This compound, known for its complex structure and intriguing properties, falls under the category of high molecular weight organic compounds. Here are some engaging insights:

  • Structural Complexity: The intricate architecture of this compound features a dodecahydrocyclopenta[a]phenanthren core, which signifies a rich variety of stereochemical nuances and functional groups that can be explored further.
  • Biological Relevance: Compounds with similar frameworks often demonstrate notable biological activities, inviting research into their potential roles as pharmaceuticals or agrochemicals.
  • Functional Modifications: This compound is a derivative that highlights the importance of functional group chemistry. The presence of sulfooxy and various alkyl substitutions may influence its reactivity and interactions with biological systems.
  • Potential Applications: Given its unique chemical properties, this compound could serve as a lead structure in drug discovery. Researchers might explore its mechanism of action and potential therapeutic uses.
  • Sustainability in Synthesis: The synthetic pathways leading to this compound can often shed light on green chemistry practices, leading chemists to seek more efficient and environmentally friendly methods for its production.

In essence, the exploration of this compound can unveil a wealth of opportunities in both academic research and practical applications, contributing to the ever-expanding field of organic chemistry. As Martin Gouterman famously said, "There's beauty in the complexity of molecular structure."