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Spironolactone

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Identification
Molecular formula
C24H32O4S
CAS number
52-01-7
IUPAC name
(17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) 3-pyrrolidin-1-ylpropanoate
State
State

Spironolactone is typically found in a solid state at room temperature. It is commonly available in the form of tablets for oral administration.

Melting point (Celsius)
133.00
Melting point (Kelvin)
406.15
Boiling point (Celsius)
605.70
Boiling point (Kelvin)
878.85
General information
Molecular weight
416.58g/mol
Molar mass
416.5770g/mol
Density
1.1217g/cm3
Appearence

Spironolactone appears as a white or off-white crystalline powder. It is generally odorless.

Comment on solubility

Solubility of (17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) 3-pyrrolidin-1-ylpropanoate

The solubility of this compound is an important aspect to consider, especially in the context of its potential applications. Generally, the solubility can vary significantly based on several factors, such as:

  • Polarity: If the compound has polar functional groups, it may exhibit enhanced solubility in polar solvents, while being less soluble in non-polar environments.
  • Temperature: Solubility often increases with temperature. Therefore, heating the solvent may lead to a greater dissolution rate.
  • pH Levels: The acidity or basicity of the solution can influence the solubility of certain compounds, perhaps leading to ionization and improved solubility.

However, due to the complex structure of this molecule, there is no vast amount of readily available data regarding its solubility in aqueous solutions or organic solvents. Additionally, the steric hindrance resulting from the bulky substituents may limit its solubility. As a result, experimental determination may be necessary for conclusive insights.

In conclusion, understanding the solubility characteristics of this compound is vital for its practical applications, especially in fields like pharmaceuticals where formulation efficacy is paramount. Therefore, conducting solubility tests under various conditions is recommended to obtain reliable information.

Interesting facts

Interesting Facts about 17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl 3-pyrrolidin-1-ylpropanoate

This fascinating compound belongs to a class of chemical substances that showcase intricate molecular architectures and diverse biological activities. Here are some intriguing aspects:

  • Synthetic Routes: Its complex structure suggests that the compound is likely synthesized through multiple steps, employing various organic chemistry techniques such as reduction, acetylation, and coupling reactions.
  • Pharmacological Potential: Many compounds that share similar structural motifs possess significant antimicrobial, anti-inflammatory, and anticancer activities. The unique arrangement of functional groups may lead to exciting therapeutic applications.
  • Cyclopenta[a]phenanthrene Framework: The core template of cyclopenta[a]phenanthrene is known for its stability and versatility in biological systems, providing the compound with intriguing properties that merit further exploration.
  • The Role of Pyrrolidine: The presence of the pyrrolidine moiety is noteworthy. Pyrrolidine derivatives often exhibit enhanced solubility, bioavailability, and receptor binding, which may contribute significantly to the compound's pharmacokinetic profile.
  • Multidisciplinary Interest: Its intricate design appeals not only to organic chemists but also to fields such as medicine, pharmacology, and materials science, thereby promoting cross-disciplinary research opportunities.

As researchers continue to delve into the properties and applications of such compounds, the potential for discovering novel therapeutic agents remains vast. The journey from synthesis to application is both challenging and rewarding, emphasizing the creativity at the heart of chemical research!