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Cortisone acetate

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Identification
Molecular formula
C21H30O8S
CAS number
50-04-4
IUPAC name
(17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) hydrogen sulfate
State
State

At room temperature, cortisone acetate is typically found in a solid state. Its crystalline form is standard for medicinal compounds, ensuring stability and ease of handling in pharmaceutical applications.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
370.90
Boiling point (Kelvin)
644.05
General information
Molecular weight
446.56g/mol
Molar mass
446.5600g/mol
Density
1.3000g/cm3
Appearence

Cortisone acetate appears as a white to off-white crystalline powder. It is odorless and has a slightly bitter taste. This appearance makes it suitable for pharmaceutical uses where the visual consistency and lack of color are important.

Comment on solubility

Solubility of (17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) hydrogen sulfate: C21H30O8S

This compound exhibits intriguing solubility characteristics that are influenced by its unique structural features. As a hydrogen sulfate, it is expected to have a degree of solubility in polar solvents. Here are some key considerations regarding its solubility:

  • Polar Solvents: The presence of the sulfate group (-SO4) generally enhances solubility in water and other polar solvents due to strong dipole interactions and potential hydrogen bonding.
  • Hydrophobic Regions: However, the compound also possesses hydrophobic characteristics from its steroid-like structure. This may limit its solubility in purely aqueous environments and contributes to a degree of amphiphilicity.
  • Solvent Selection: It may dissolve better in solvents such as ethanol or dimethyl sulfoxide (DMSO), which can balance the polar and non-polar components of the molecule.

In summary, the solubility of C21H30O8S is a complex interplay between its hydrophilic sulfate group and hydrophobic steroid backbone. As emphasized, proper solvent selection is crucial for desired dissolution outcomes, and exploring various solvent systems could yield effective applications in chemical synthesis and formulation.

Interesting facts

Interesting Facts about 17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl hydrogen sulfate

This compound, often associated with advanced chemical study, represents a fascinating intersection of organic chemistry and pharmacology. Here are some compelling points to consider:

  • Structure Complexity: The intricate *polycyclic structure* of this compound showcases the beauty of organic molecules. The presence of multiple rings, including cyclopenta[a]phenanthrene, allows for a range of potential interactions with biological systems.
  • Functional Group Diversity: With the incorporation of an acetyl group and a hydrogen sulfate moiety, this compound exhibits a fusion of lipophilic and hydrophilic properties. This duality can influence its *bioavailability* and interact with various biological receptors.
  • Pharmacological Potential: Compounds like this one are often studied for their potential therapeutic effects. The modifications in the ring structure may offer insights into new drug development avenues, particularly in areas like *oncology* and *hormonal modulation*.
  • Synthesis Importance: The methods used to synthesize such complex organic molecules often involve multi-step reactions and the implementation of various synthetic techniques. Understanding these processes is crucial for chemists aiming to create similar compounds or derivatives.
  • Research Application: The unique structure leads to various *research applications*, providing a platform for scientists to explore the fundamental aspects of chemical interactions and their implications in medicinal chemistry.

In summation, the study of 17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl hydrogen sulfate opens doors to a myriad of scientific inquiries and potential innovations in therapeutic development. This compound reflects the complexity and relevance of organic chemistry in modern science.

Synonyms
CHEMBL141573
SCHEMBL20503211
DIJBBUIOWGGQOP-UHFFFAOYSA-N
BAA24764
(17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl) hydrogen sulfate