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Chlormadinone acetate

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Identification
Molecular formula
C23H29ClO4
CAS number
302-22-7
IUPAC name
(17-acetyl-6-chloro-10,13-dimethyl-3-oxo-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-17-yl) acetate
State
State

At room temperature, chlormadinone acetate is in a solid state. It is generally stable and should be handled with appropriate precautions as typical with pharmaceutical compounds.

Melting point (Celsius)
207.00
Melting point (Kelvin)
480.15
Boiling point (Celsius)
580.15
Boiling point (Kelvin)
853.30
General information
Molecular weight
404.93g/mol
Molar mass
404.9480g/mol
Density
1.3700g/cm3
Appearence

Chlormadinone acetate typically appears as a white to off-white crystalline powder. It is odorless and stable under normal storage conditions. The compound is relatively insoluble in water but is soluble in organic solvents.

Comment on solubility

Solubility of 17-acetyl-6-chloro-10,13-dimethyl-3-oxo-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-17-yl acetate

The solubility of the compound (17-acetyl-6-chloro-10,13-dimethyl-3-oxo-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-17-yl) acetate can be influenced by various factors, including its molecular structure and the nature of solvents used during testing. Here are some key points to consider:

  • Polarity: The presence of the acetate group often enhances the compound's interaction with polar solvents, potentially leading to higher solubility in these environments.
  • Hydrophobic Characteristics: The hexahydro-cyclopenta component suggests a significant hydrophobic character, which may limit solubility in water but increase solubility in organic solvents such as ethanol or dimethyl sulfoxide.
  • Temperature Effects: As with many organic compounds, solubility may increase with temperature, allowing for greater dissolution in solvent at elevated temperatures.

In summary, while the compound's specific solubility characteristics may vary, a careful examination of solvent choice and environmental conditions is required to fully understand its behavior in solution. As with all organic compounds, empirical testing is necessary to determine precise solubility values.

Interesting facts

Interesting Facts about 17-acetyl-6-chloro-10,13-dimethyl-3-oxo-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-17-yl Acetate

This complex compound belongs to a class known for its interesting bioactive properties and synthetic challenges. Notably, it features a unique structure that highlights the fascinating interplay between steroids and cyclic hydrocarbons, showcasing the art of organic synthesis.

Key Highlights:

  • Steroidal Framework: This compound is derived from a steroidal backbone, which has crucial implications in biochemistry, notably in hormone function and pharmaceutical applications.
  • Synthetic Intricacies: The multi-step synthesis of such compounds often involves advanced techniques like organometallic reactions and selective reductions, demonstrating the artistry and skill required in organic chemistry.
  • Chlorine Substitution: The presence of chlorine not only impacts the compound's reactivity but also enhances its bioactivity, making it a point of interest in medicinal chemistry.
  • Bioactivity Potential: Research has suggested that similar structures exhibit properties such as anti-inflammatory, anti-tumor, and hormone regulatory effects, inviting further investigation into this compound's potential.

Furthermore, the architecture of the compound allows for interactions that may exhibit selectivity in biological systems, making it a candidate for drug development. It serves as a reminder of the complexity and beauty of chemical structures, inspiring further exploration and innovation in the field of organic chemistry.

As scientists continue to unravel the specific mechanisms of this compound and its derivatives, we can anticipate exciting advancements in therapeutic applications stemming from its unique molecular design.

Synonyms
6-chloro-3,20-dioxopregna-1,4,6-trien-17-yl acetate
SCHEMBL146081
DTXSID90864431
CGBCCZZJVKUAMX-UHFFFAOYSA-N
STL454152