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Chlormadinone acetate

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Identification
Molecular formula
C23H29ClO4
CAS number
302-22-7
IUPAC name
17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, chlormadinone acetate is typically in a solid state, appearing as a fine crystalline powder.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
455.20
Boiling point (Kelvin)
728.35
General information
Molecular weight
405.93g/mol
Molar mass
404.9790g/mol
Density
1.2800g/cm3
Appearence

Chlormadinone acetate is a white to off-white crystalline powder. It is practically insoluble in water, slightly soluble in alcohol, and freely soluble in chloroform and dioxane.

Comment on solubility

Solubility Characteristics of 17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one

The solubility of the compound 17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one exhibits intriguing features based on its chemical structure and functional groups. Here are some key points to consider:

  • Polar vs. Non-Polar Solvents: This compound contains both polar functional groups (like the hydroxy group) and non-polar hydrocarbon rings, suggesting it may have variable solubility in different solvents.
  • Aqueous Solubility: Due to its large hydrophobic carbon framework, the solubility in water is likely to be quite low. The presence of polar hydroxyl and carbonyl groups may slightly enhance its solubility in water but not significantly.
  • Organic Solvents: It is expected to exhibit good solubility in non-polar organic solvents such as hexane, chloroform, or ether, where the hydrophobic regions can interact effectively with the solvent.
  • Concentration Dependence: The solubility may also depend on the concentration, with higher concentrations potentially leading to precipitation in polar solvents.

Overall, the solubility of 17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one is a complex interplay of its structural characteristics combined with the nature of the solvent used. It highlights the importance of considering both the chemical composition and the environment when determining solubility potential.

Interesting facts

Interesting Facts About 17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one

17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one, often referred to in scientific circles due to its complexity, is a fascinating compound with intriguing characteristics and applications. Below are some interesting insights:

  • Structure and Stability: The structure of this compound features a unique fusion of a cyclopenta[a]phenanthrene core. This intricate architecture contributes to its stability, which is essential for its biological activity.
  • Biological Activity: Compounds similar to this one are often studied for their potential therapeutic benefits, particularly in oncology. Their ability to interact with biological pathways makes them candidates for cancer research.
  • Chirality: This compound may possess chiral centers, which means it can exist in multiple forms that might exhibit different biological activities. Understanding chirality is crucial in the development of pharmaceuticals.
  • Synthesis Strategies: The synthesis of such complex molecules involves advanced organic chemistry techniques. Researchers often employ methods such as functional group transformations and stereoselective synthesis to achieve the desired structure.
  • Research Interest: Due to its complex nature, this compound is often a subject of study in medicinal chemistry and pharmacology, offering insights into drug design and discovery.
  • Potential Applications: Aside from its potential role in cancer treatment, compounds of this nature can be explored for other medical applications, including anti-inflammatory and antimicrobial activities.

Overall, 17-acetyl-6-chloro-17-hydroxy-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthren-3-one exemplifies the complexity and beauty of organic chemistry, showcasing how intricate structures can lead to significant advancements in medicinal science.

Synonyms
DTXSID40864567