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Chlormadinone acetate

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Identification
Molecular formula
C23H29ClO4
CAS number
302-22-7
IUPAC name
17-acetyl-6-chloro-17-hydroxy-10,13,16-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, chlormadinone acetate is in a solid state. Its solid form is suitable for its use in medicinal applications, particularly in oral contraceptives and hormone therapies.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.00
Boiling point (Celsius)
460.00
Boiling point (Kelvin)
733.00
General information
Molecular weight
405.94g/mol
Molar mass
405.9570g/mol
Density
1.3000g/cm3
Appearence

Chlormadinone acetate appears as a white to creamy-white crystalline powder. It is practically insoluble in water, making it stable in its solid form. The compound is often used in its fine powder state, especially when formulated for pharmaceutical applications.

Comment on solubility

Solubility of 17-acetyl-6-chloro-17-hydroxy-10,13,16-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of 17-acetyl-6-chloro-17-hydroxy-10,13,16-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one presents a fascinating investigation in the realm of chemical compounds. Understanding its solubility is essential for applications in various fields including pharmacology and chemical synthesis.

Factors Influencing Solubility

  • Polarity: The presence of functional groups may enhance or reduce its overall polarity, impacting its ability to dissolve in polar or non-polar solvents.
  • Hydrogen Bonding: The hydroxyl (-OH) group can engage in hydrogen bonding, potentially increasing solubility in aqueous environments.
  • Molecular Size: Larger molecules often display lower solubility due to steric hindrance, affecting their interactions with solvent molecules.

Generally, this compound may exhibit limited solubility in water due to its complex structure and larger hydrophobic regions. Consequently, it might be more soluble in organic solvents like ethanol or DMSO (dimethyl sulfoxide).

In summary: The solubility behavior of this compound is determined by a fine balance between intermolecular forces, molecular structure, and environmental conditions. Exploration into these aspects can yield valuable insights for its practical applications.

Interesting facts

Interesting Facts about 17-acetyl-6-chloro-17-hydroxy-10,13,16-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one

This compound, which falls under the category of synthetic steroids, has garnered attention in various fields, including medicinal chemistry. Here are some compelling facts about it:

  • Synthetic Derivative: It is a synthetic derivative of natural steroid hormones, showcasing human ingenuity in modifying molecular structures for specific biological effects.
  • Potential Applications: This compound has potential applications in hormone replacement therapies, particularly in treating conditions related to hormonal imbalances.
  • Pharmacological Activity: Researchers are interested in its pharmacological activity—specifically how modifications to its structure can influence its interaction with steroid receptors.
  • Chirality and Stereoisomerism: The presence of multiple chiral centers in its structure presents fascinating challenges in stereochemistry, often impacting its biological activity and effectiveness.
  • Environmental Stability: Understanding how it behaves in various environmental conditions is crucial for assessing its suitability in therapeutics as well as potential ecological impacts.

Overall, the modification of the steroid nucleus in this compound reflects a deeper understanding of chemistry and biology, contributing to developments in pharmaceuticals and therapeutic strategies. This compound exemplifies the balance between chemical innovation and the drive for effective medical solutions.


Synonyms
Pregna-4,6-diene-3,20-dione,6-chloro-17- hydroxy-16-methyl-,(16R)-
DTXSID90863525
NS00121696
6-chloro-17-hydroxy-16-methylpregna-4,6-diene-3,20-dione