Skip to main content

Triamcinolone

ADVERTISEMENT
Identification
Molecular formula
C24H31FO6
CAS number
124-94-7
IUPAC name
(17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl) acetate
State
State

At room temperature, triamcinolone is a solid. It is typically handled as a fine powder in its pure form, often used in pharmaceutical formulations.

Melting point (Celsius)
274.00
Melting point (Kelvin)
547.00
Boiling point (Celsius)
625.20
Boiling point (Kelvin)
898.20
General information
Molecular weight
404.50g/mol
Molar mass
404.5000g/mol
Density
1.3030g/cm3
Appearence

Triamcinolone appears as a white or almost white crystalline powder. It is practically insoluble in water, slightly soluble in methanol and acetone, and soluble in dioxane. The powder may exhibit some light sensitivity, requiring storage away from direct sunlight.

Comment on solubility

Solubility Characteristics

The compound (17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta [a] phenanthren-17-yl) acetate exhibits interesting solubility properties, which can vary based on solvent choice and temperature. Understanding these solubility characteristics is crucial for practical applications.

Factors Influencing Solubility

  • Polarity: The presence of acetyl and acetate functional groups enhances the polarity of this compound, allowing it to interact more readily with polar solvents.
  • Temperature: Solubility is typically temperature-dependent; thus, heating the solvent may increase the solubility of this compound.
  • Solvent Type: This compound may find better solubility in organic solvents such as methanol or ethanol due to their compatible polarities.

General Observations

In general, the solubility of organic compounds like this one can be summarized as follows:

  • Highly soluble in polar solvents, especially at elevated temperatures.
  • Moderately soluble in less polar solvents.
  • Poorly soluble in non-polar solvents due to lack of favorable interactions.

Overall, the solubility of (17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta [a] phenanthren-17-yl) acetate is determined by its molecular structure and the surrounding solvent environment, making it essential to conduct solubility tests under specific conditions for precise applications.

Interesting facts

Interesting Facts about 17-Acetyl-6,10,13-trimethyl-16-methylene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl Acetate

This compound, while complex in its name, embodies a fascinating intersection of chemistry and biological activity. Here are some interesting insights that highlight its significance:

  • Biological Activity: This compound has attracted attention for its potential biological properties, particularly in the field of medicinal chemistry. Studies have suggested that compounds with similar structures may exhibit anti-inflammatory and anti-cancer activities.
  • Structural Complexity: The intricate structure features multiple methyl groups and a cyclopenta[a]phenanthrene core, which is significant in the study of steroid-like compounds and their derivatives.
  • Derivative Potential: The presence of the acetyl group enhances the compound's reactivity, making it a candidate for further chemical modifications, which could lead to new derivatives with enhanced properties.
  • Scientific Interest: The systematic study of the synthesis and reactions involving such structurally rich compounds can shed light on reaction mechanisms in organic chemistry, making it of interest to both chemists and biochemists.

As noted in scientific literature, "the elegance of complexity in chemical structures often leads to innovative pharmaceutical discoveries." This highlights the importance of continued research into compounds like 17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl acetate, which may open avenues for developing novel therapeutic agents.

In summary, this compound exemplifies the rich tapestry of organic chemistry, where detailed structural features can have profound implications in research and development.

Synonyms
MGA, veterinary
Malengestrol Acetate
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-16-methylene-, acetate
MGA
NCIOpen2_008323
CHEMBL4740893
DTXSID60859778
(17-acetyl-6,10,13-trimethyl-16-methylene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl) acetate
6-Methyl-16-methylene-3,20-dioxopregna-4,6-dien-17-yl acetate
6-methyl-16-methylidene-3,20-dioxopregna-4,6-dien-17-yl acetate
Progesterone, 6-dehydro-17-hydroxy-6-methyl-16-methylene-, acetate
17-Hydroxy-6-methyl-16-methylenepregna-4,6-diene-3, 20-dione acetate
Pregna-4, 6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-16-methylene-