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Dexamethasone

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Identification
Molecular formula
C22H29FO5
CAS number
50-02-2
IUPAC name
17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, dexamethasone is in a solid state, specifically as a crystalline powder. It is stable under normal conditions.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
392.47g/mol
Molar mass
392.4650g/mol
Density
1.3100g/cm3
Appearence

Dexamethasone is generally a white to practically white, odorless crystalline powder. Its appearance may vary slightly depending on its form and purity.

Comment on solubility

Solubility of 17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one (C22H29FO5)

The solubility characteristics of 17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one are quite intriguing due to its complex molecular structure. Here are some key points to consider:

  • Solvent Compatibility: This compound is likely to exhibit significant solubility in organic solvents such as ethanol, methanol, and acetonitrile.
  • Polarity: Given its hydroxyl (-OH) groups, the compound may present some degree of polarity, suggesting partial solubility in polar solvents, while also potentially remaining soluble in non-polar solvents due to its hydrocarbon and fluorinated regions.
  • Temperature Effects: As with many organic compounds, solubility can be enhanced with increased temperature, which may lead to improved dissolution rates and concentrations.
  • pH Influence: The presence of hydroxyl groups might also mean that the solubility can be influenced by the pH of the solution, typical for compounds with acidic or basic functionalities.

Understanding the solubility of this compound is essential for its application in various fields, particularly in pharmaceuticals where solubility plays a critical role in bioavailability. As always, experimentation under specific conditions is necessary to establish precise solubility parameters.

Interesting facts

Interesting Facts about 17-Acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

This unique compound, often referred to in research settings, has garnered attention for a variety of compelling reasons. Here are some notable aspects:

  • Pharmaceutical Applications: This compound plays a crucial role in the development of corticosteroids, which are widely used in medicine for their anti-inflammatory and immunosuppressive properties.
  • Fluorine Substitution: The presence of the fluorine atom enhances the metabolic stability of the compound, making it a subject of interest for medicinal chemists looking to improve drug efficacy.
  • Multi-Hydroxyl Groups: The dihydroxy groups in its structure contribute to the compound's potential interactions in biological systems, which can influence its pharmacological activity.
  • Cyclic Structures: The cyclopenta[a]phenanthrene framework provides interesting stereochemistry that can affect how the compound interacts with biological targets.

In the words of one researcher, "The intricate structure of this compound is a testament to the fascinating world of organic chemistry and highlights the importance of functional groups in drug design."
As a student of chemistry, studying compounds like this offers insight not only into organic synthesis but also into potential therapeutic pathways, revealing how modifications can lead to significant changes in biological activity.

Overall, the detailed examination of compounds like 17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one opens up avenues for innovative research and pharmaceutical advancements.

Synonyms
Fluoromethalone
Efflumidex
MLS002702836
SMR001563899
Fluormetholon
17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
6beta-MethylFluorometholone
FML S.O.P.
Fluaton
Loticort
Ursnon
Neo-Oxylone (Salt/Mix)
cid_3384
FML-S Liquifilm (Salt/Mix)
CHEMBL1716015
SCHEMBL13026152
BDBM91406
DTXSID70859360
FAOZLTXFLGPHNG-UHFFFAOYSA-N
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17-dihydroxy-6.alpha.-methyl-
HMS3259N12
AKOS030228671
NC00725
LS-14959
DB-050948
6.alpha.-Methyl-9.alpha.-fluoro-21-desoxyprednisolone
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione, (6.alpha.,11.beta.)- #
9-Fluoro-11.beta.,17-dihydroxy-6.alpha.-methylpregna-1,4-diene-3,20-dione
(6.alpha.,9.alpha.,11.beta.,17.alpha.)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione