Skip to main content

Epothilone B

ADVERTISEMENT
Identification
Molecular formula
C27H41NO6
CAS number
152044-53-6
IUPAC name
17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
State
State

At room temperature, Epothilone B is a solid. It is usually handled in a dry form to maintain its stability and purity.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
531.20
Boiling point (Kelvin)
804.35
General information
Molecular weight
593.82g/mol
Molar mass
593.8190g/mol
Density
1.2970g/cm3
Appearence

Epothilone B is a pale yellow powder or crystalline solid. It can also appear as a colorless to yellow solution depending on the medium it is in. It is generally insoluble in water but soluble in alcohols and most organic solvents.

Comment on solubility

Solubility of 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone (C27H41NO6)

The solubility of this complex compound is influenced by its unique structural characteristics and functional groups. Here are some key points to consider:

  • Polarity: The presence of hydroxyl (-OH) groups typically increases water solubility due to their ability to form hydrogen bonds with water molecules.
  • Aromatic and aliphatic structures: The compound contains both cyclic and acyclic segments, which may affect its interaction with non-polar solvents.
  • Solvent compatibility: It may exhibit differential solubility, being more soluble in organic solvents than in water.

In general, the solubility of complex organic compounds such as this one can often be described in terms of the concept “like dissolves like,” meaning:

  1. Compounds with similar polarities tend to dissolve in each other.
  2. Hydrophobic portions may resist solubility in polar solvents.

In practical applications, determining the solubility of 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone in various solvents would require experimental assessment, considering factors such as temperature, concentration, and the nature of the solvent.

Interesting facts

Interesting Facts about 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone

This intricate compound, with its long and detailed name, illustrates the complexity and beauty found within organic chemistry. Below are some fascinating insights into this remarkable molecule:

  • Structural Complexity: The compound features multiple functional groups, including hydroxyl groups and methoxy groups, highlighting its potential for unique reactivity. Its intricate framework may contribute to intriguing chemical properties and biological activities.
  • Pharmacological Potential: Given its diverse structural features, compounds of this nature are often researched for their pharmaceutical properties. They may exhibit effects on various biological pathways, paving the way for new therapeutic agents.
  • Natural Inspirations: Many compounds with complex structures are derived from natural sources, often serving as a starting point for drug design or synthesis in medicinal chemistry.
  • Analytical Challenges: The significant molecular weight and structural intricacy of this compound can pose challenges in analysis, necessitating advanced techniques such as NMR spectroscopy or mass spectrometry for identification and characterization.
  • Chemical Diversity: The variety in substitution patterns on the cyclohexyl ring and the presence of various functional groups illustrate the potential for creating numerous analogs, leading to a rich field of study.

The exploration of such a compound not only highlights the depth of organic chemistry but also encourages a deeper understanding of how molecular structure influences function and reactivity in biological systems. As we continue to uncover the roles of complex molecules, the journey remains as thrilling as the discoveries themselves.

Synonyms
104987-11-3
19-Epi FK-506
144490-63-1
1,14-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone
FK-506 (Tacrolimus)
MFCD00869853
INT-3098-PI
QJJXYPPXXYFBGM-UHFFFAOYSA-N
UFA49063
SY069910
1,14-dihydroxy-12-[1-(4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0?,?]octacos-18-ene-2,3,10,16-tetrone
17-allyl- 1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone
17-allyl-1,14-di-hydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9] octacos-18-ene-2,3,10,16-tetraone
17-Allyl-1,14-di-hydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-vinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetraone
17-allyl-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxy -cyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone
17-allyl-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,-27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone
17-allyl-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene-2,3,10,16-tetraone
17-allyl-1,14-dihydroxy-12-[2'-(4"-hydroxy-3"-methoxycyclohexyl)-1'-methylvinyl]23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]-octacos-18-ene-2,3,10,16-tetraone