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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol
State
State

At room temperature, Loperamide is in a solid state.

Melting point (Celsius)
216.00
Melting point (Kelvin)
489.15
Boiling point (Celsius)
482.50
Boiling point (Kelvin)
755.70
General information
Molecular weight
477.03g/mol
Molar mass
477.0340g/mol
Density
1.2100g/cm3
Appearence

Loperamide is generally found as a white or off-white powder. It is typically odorless and has a bitter taste. The compound can be formulated into various dosage forms, including tablets and capsules, for medical applications.

Comment on solubility

Solubility of 1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol

The solubility of 1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol can vary based on several factors, including temperature, pH, and the presence of other solutes. Here are some key points to consider:

  • Polar vs. Nonpolar Solvents: This compound, due to its large and complex structure, is likely to exhibit limited solubility in water, which is a polar solvent. However, it may be more soluble in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • Functional Groups: The presence of multiple dimethylamino groups indicates potential for polarity, which can enhance solubility in polar environments. However, the bulky aromatic groups may hinder complete solvation.
  • Temperature Effects: Typically, an increase in temperature can enhance solubility, especially for solids. Experimentation would be required to determine the precise solubility limits.
  • pH Influence: The solubility could also be affected by pH, especially if the compound ionizes under certain conditions, thereby increasing solubility in aqueous solutions.

In summary, while 1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol may show variable solubility based on environmental factors, extensive empirical studies would provide the most accurate insights into its solubility characteristics. As a rule of thumb, "like dissolves like," so exploring its behavior in similar polar or nonpolar media would be a good first approach.

Interesting facts

Exploring 1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol

This complex organic compound, known as 1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol, presents an intriguing blend of structural features, making it a subject of considerable interest in the field of organic chemistry. Here are some noteworthy aspects:

  • Multi-functional Nature: The compound contains both amine and alcohol functional groups, allowing it to participate in a variety of chemical reactions and making it a potential candidate for various applications in medicinal chemistry.
  • Structural Complexity: Its structure features multiple aromatic rings, contributing to its molecular complexity. This complexity often results in interesting electronic properties and potential for specific interactions with biological targets.
  • Pharmaceutical Potential: Due to its functional groups and structural characteristics, there is a potential application in drug design, especially in developing compounds that can cross the blood-brain barrier.
  • Dimethylamino Groups: The presence of dimethylamino groups enhances its basicity and can improve solubility in various solvents, which is a crucial factor in farmacokinetics.

Overall, 1,7-bis(dimethylamino)-4-[2-(2-phenylethyl)phenyl]heptan-4-ol serves as a perfect example of how intricate molecular designs can lead to unique chemical properties. Scientists continue to explore such compounds for their potential roles in therapeutic applications, showcasing the intricate relationship between structure and function in chemical science.