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Norethisterone

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Identification
Molecular formula
C20H26O2
CAS number
68-22-4
IUPAC name
17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, Norethisterone is typically found in a solid state.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
65.60
Boiling point (Kelvin)
338.80
General information
Molecular weight
298.43g/mol
Molar mass
298.4300g/mol
Density
1.1300g/cm3
Appearence

Norethisterone usually appears as a white to creamy-white, odorless, crystalline powder.

Comment on solubility

Solubility of 17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one (C20H26O2)

The solubility of the compound 17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one, characterized by its complex structure, can be influenced by various factors including temperature and the solvent used. Here are some key points regarding its solubility:

  • Solvent Type: This compound may show variable solubility in polar versus non-polar solvents, often being more soluble in organic solvents such as ethanol or dichloromethane due to its hydrophobic characteristics.
  • Temperature Impact: Generally, increasing the temperature tends to enhance solubility. This phenomenon is particularly relevant for solid compounds like this one.
  • pH Levels: The solubility can also depend on the pH of the solution. In acidic or alkaline conditions, it may undergo protonation or deprotonation, altering its solubility properties.
  • Crystallinity: A highly crystalline form of this compound may exhibit lower solubility compared to its amorphous counterparts due to the energy required to disrupt the organized structure.

In summary, the solubility of C20H26O2 is not uniform and requires careful evaluation under specific conditions. As a general observation, it is crucial to conduct solubility tests in the desired solvent system to obtain accurate and reliable results. Understanding these properties is essential for practical applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 17-Ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This complex compound is a member of the class of sterols and steroid derivatives, which are known for their essential roles in biological systems. In the pharmaceutical field, compounds like this are of great interest due to their potential *biological activities*, including hormonal functions and their roles as therapeutic agents.

Key Features:

  • Synthetic Steroid: Its structure showcases a steroid backbone, which is crucial for its interaction with biological receptors.
  • Hormonal Activity: This compound is structurally related to *progesterone*, a key hormone in the reproductive system, suggesting its potential use in hormone therapies.
  • Ethynyl Group: The presence of an ethynyl group in the compound enhances its *lipophilicity*, potentially affecting its metabolic stability and biological activity.
  • Research Applications: Investigations into this compound may lead to advances in treatments for conditions related to *hormonal imbalances* and reproductive health.

Moreover, the intricate cyclopenta[a]phenanthrene moiety is a fascinating aspect that provides unique steric and electronic properties, making it a subject of interest in synthetic organic chemistry. The compound could serve as a prototype for the design of new drugs that aim to modulate *hormonal pathways*.

In summary, the study of 17-ethynyl-17-hydroxy-7,13-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one can pave the way for innovative therapeutic applications that address various health issues.

Synonyms
DTXSID70859921
17-Hydroxy-7.alpha.-methyl-19-nor-17.alpha.-pregn-5(10)-en-20-yn-3-one
WZDGZWOAQTVYBX-UHFFFAOYSA-N
Tibolone ;Org OD 14;Org OD14
BCP04568
17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one