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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, corticosterone is in a solid state, appearing as a white crystalline powder.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.00
Boiling point (Celsius)
580.00
Boiling point (Kelvin)
853.00
General information
Molecular weight
346.47g/mol
Molar mass
346.4670g/mol
Density
1.2000g/cm3
Appearence

Corticosterone is typically a white crystalline powder. It is a steroid hormone and has a solid form at room temperature with a defined crystalline structure.

Comment on solubility

Solubility of 17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

The solubility of 17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one (C21H30O4) can be understood through various key points:

  • Polar vs. Nonpolar Solvents: This compound's structure suggests a significant nonpolar component due to the extensive hydrocarbon (alkane) chains, which often leads to low solubility in polar solvents such as water.
  • Possible Solvent Compatibility: It is more likely to be soluble in nonpolar solvents or organic solvents like hexane or chloroform, given its hydrophobic nature.
  • Temperature Influence: The solubility may increase with temperature, as is common with many organic compounds, affecting the molecular interactions with the solvent.
  • Hydrogen Bonding: The presence of hydroxyl groups can introduce some degree of solubility in polar solvents through hydrogen bonding, although this effect may be limited due to the dominating hydrocarbon character of the compound.

In summary, the solubility of C21H30O4 is expected to be more favorable in nonpolar organic solvents than in water, and its solubility behavior may vary based on temperature and solvent environment.

Interesting facts

Interesting Facts about 17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

This compound is a fascinating example of a sterol derivative, particularly related to the family of steroids. Known for its complex structure, this molecule showcases the intricate beauty of organic chemistry with its multiple rings and functional groups.

Key Highlights:

  • Steroidal Framework: The compound contains a steroidal backbone, which is fundamental in many biological molecules, including hormones and vitamins.
  • Hydroxyl Functionality: The presence of the hydroxyl group (–OH) at the 17th position is significant as it can influence both the reactivity and the biological activity of the compound.
  • Trimethyl Groups: The three methyl (–CH3) groups at the 10th, 13th, and 17th positions not only affect the physical properties but also contribute to the steric hindrance, which plays a role in its biological function.
  • Potential Biological Activity: Compounds like this one can mimic or interact with hormonal pathways in living organisms, making them of interest in pharmacology and therapeutic research.

In the realm of organic synthesis, the construction of such complex molecules often serves as a testament to the advancements within chemical methodologies. Techniques such as stereochemistry and functional group manipulation allow chemists to not only understand these compounds but also to design and synthesize new derivatives with potentially enhanced properties.

Furthermore, it is intriguing to note that the study of such compounds requires a solid understanding of nuclear magnetic resonance (NMR) and mass spectrometry, which are crucial in elucidating their structure and confirming the effectiveness of synthetic routes used in their preparation.

In summary, 17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one stands as a remarkable structure embodying the sophistication of organic chemistry and its profound implications in the scientific exploration of bioactive compounds.

Synonyms
17-Hydroxy-17-methylandrostan-3-one
Mestaline
NCGC00183127-01
NCIOpen2_007528
DAA27558
AKOS015998321
LS-14823
DB-052072
NS00134355