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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State
Solid at room temperature.
Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
548.20
Boiling point (Kelvin)
821.35
General information
Molecular weight
346.47g/mol
Molar mass
346.4670g/mol
Density
1.2720g/cm3
Appearence

An off-white to pale yellow crystalline powder. It is generally odorless.

Comment on solubility

Solubility of 17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one (C21H30O4)

The solubility of 17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one exhibits unique characteristics due to its chemical structure and functional groups. Generally, solubility in solvents can be influenced by several factors, which include:

  • Molecular structure: The presence of hydroxyl groups can enhance solubility in polar solvents like water, while hydrophobic regions may favor non-polar solvents.
  • Polarity: An increase in polarity typically correlates with increased solubility in polar solvents. Conversely, non-polar solvents are more likely to dissolve non-polar substances.
  • Temperature: Higher temperatures can increase the solubility of many compounds, allowing for greater molecular interaction.
  • pH Levels: The solubility of compounds with acidic or basic properties may vary significantly with changes in pH.

In the case of C21H30O4, it can be observed that:

  • The hydroxyl group (-OH) adds polar characteristics, making it more soluble in aqueous environments.
  • However, the bulky cyclopentaphenanthrene structure presents challenges for solubility in strictly polar solvents.

In summary, to predict the solubility of 17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one, one must consider the balance between its polar functional groups and its hydrophobic hydrocarbon skeleton.

Interesting facts

Interesting Facts about 17-Hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This fascinating compound is known primarily in the realm of steroid chemistry and is often studied for its unique structure and biological activities. Here are some intriguing facets:

  • Biological Significance: This compound, often referred to as a steroid, plays a vital role in various physiological processes, particularly in the endocrine system. Its hydroxyl group at the 17-position can significantly influence its interaction with steroid receptors.
  • Structural Complexity: With its intricate multi-ring structure, this compound exhibits features typical of steroids, contributing to its diverse biological functions. The numerous methyl groups affect both its solubility and how it interacts with other molecules.
  • Research Applications: Scientists often investigate this compound in relation to its potential therapeutic uses. Its analogs have been examined for their anti-inflammatory, anticancer, and anabolic properties, making it a subject of interest in pharmacological research.
  • Synthesis Challenge: The synthesis of compounds like this can be complex, requiring advanced organic chemistry techniques. Understanding the mechanisms of its formation can be crucial for chemists looking to develop novel compounds with similar activity.
  • Historical Context: Many derivatives of this compound paved the way for the development of synthetic steroids, which have revolutionized medicine, particularly in areas such as hormone replacement therapy and sports medicine.
  • Unique Isomerism: The specific arrangement of atoms in this compound allows for multiple isomers, each with its own unique properties. This is a testament to the complexity and diversity found within organic chemistry.

As quoted by renowned chemist Linus Pauling: "The best way to have a good idea is to have a lot of ideas." The study of compounds such as this challenges chemists to explore further, leading to breakthroughs in both science and medicine.

The exploration of this compound is a gateway to understanding larger biological systems and the development of new therapeutic agents. Continuing research on such molecules promises to yield exciting advancements in health and science.

Synonyms
17-hydroxy-10,13,17-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Androst-4-en-3-one, 17-hydroxy-17-methyl-, (17beta)-
17?-Methyltestosterone
SCHEMBL5021655
CHEBI:125362
GCKMFJBGXUYNAG-UHFFFAOYSA-N
AKOS024481972
Methyltestosterone;17-Methyltestosterone
NCGC00249275-01
NCGC00249275-02
LS-14818
PD056078
DB-053167
VU0609043-1
BRD-A08062015-001-01-0
F3292-0438
Androsten-17-(beta)-ol-3-one, 17(alpha)-methyl-delta^4-
Androsten-17-(beta)-ol-3-one, 17(alpha)-methyl-delta4-
1-HYDROXY-1,9A,11A-TRIMETHYL-1H,2H,3H,3AH,3BH,4H,5H,7H,8H,9H,9AH,9BH,10H,11H,11AH-CYCLOPENTA[A]PHENANTHREN-7-ONE
17-hydroxy-10,13,17-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one