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Estrone sulfate

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Identification
Molecular formula
C18H22O5S
CAS number
438-67-5
IUPAC name
(17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate
State
State

At room temperature, estrone sulfate is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
262.50
Melting point (Kelvin)
535.65
Boiling point (Celsius)
872.00
Boiling point (Kelvin)
1 145.15
General information
Molecular weight
350.47g/mol
Molar mass
350.4690g/mol
Density
1.4000g/cm3
Appearence

Estrone sulfate typically appears as a white or almost white crystalline powder.

Comment on solubility

Solubility of (17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate

The solubility of the compound (17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate, with the chemical formula C18H22O5S, can be evaluated based on several factors:

  • Polarity: The presence of the hydrogen sulfate moiety contributes to an increase in polarity, which often aids in solubility in polar solvents, such as water.

  • Functional Groups: The hydroxyl group (-OH) is another feature that enhances hydrogen bonding interactions with solvent molecules.

  • Hydrophobic Regions: However, the decahydrocyclopenta[a]phenanthren group presents a larger hydrophobic section that may hinder complete solubility in highly polar solvents.

  • Influence of Temperature: Like many organic compounds, the solubility may increase with temperature, so warm solvents could dissolve more of this compound.

In general, one might expect this compound to be moderately soluble in polar solvents, while potentially having limited solubility in non-polar liquids. To sum up, the solubility behavior can often be complex and is influenced by the balance between hydrophilic and hydrophobic characteristics. Testing in different solvents would provide more accurate solubility data and enhance practical applications.

Interesting facts

Interesting Facts about 17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl Hydrogen Sulfate

This complex organic compound is primarily notable for its role in the field of biochemistry and its potential applications in medicinal chemistry. Here are some fascinating insights:

  • Steroidal Structure: This compound belongs to the sterol family, which is essential for various biological functions, including serving as precursors for hormones like corticosteroids and sex hormones.
  • Biological Activity: Compounds similar to this structure are known for their interactions with steroid receptors, making them potential candidates for drug development aimed at treating hormonal imbalances and related diseases.
  • Functional Groups: The presence of a hydrogen sulfate moiety indicates that this compound may exhibit unique solubility properties and can participate in various chemical reactions, potentially affecting its biological activity.
  • Synthetic Pathways: Understanding the synthesis of this compound can enhance our knowledge of pharmaceutical chemistry, especially concerning the creation of specialized steroids used in therapy.
  • Research Significance: Compounds like this one are often subjects of pharmacological research as scientists seek to uncover new treatments for various conditions, including inflammation, stress response, and hormonal therapies.

As one delves deeper into the world of organic chemistry, molecules such as this highlight the intricacies of biological systems and the power of small changes in molecular structure to yield significant effects in biological activity. “The right molecule can change everything.”

Synonyms
17-hydroxyestra-1,3,5(10)-trien-3-yl hydrogen sulfate
ESTRADIOL 3-SULFATE
Estradiol 17 sulfate
CHEMBL1160043
DTXSID00274320
(17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate