Skip to main content

Hydrocortisone

ADVERTISEMENT
Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
State
State

At room temperature, hydrocortisone is in a solid state. It is typically handled as a powder for pharmaceutical formulations.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
620.00
Boiling point (Kelvin)
893.15
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.1200g/cm3
Appearence

Hydrocortisone appears as a white to practically white, odorless, crystalline powder. It is light-sensitive and gradually darkens on exposure to light. It is also sparingly soluble in water, sparingly soluble in alcohol, and slightly soluble in acetone and in methylene chloride.

Comment on solubility

Solubility of 17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione (C21H30O5)

The solubility of a compound often plays a crucial role in its application and function. In the case of 17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione, various factors influence its solubility profile:

  • Polarity: The presence of multiple hydroxyl (-OH) groups imbues the compound with polar characteristics, typically enhancing solubility in polar solvents such as water.
  • Hydrophobic Regions: The hydrocarbon parts of the molecule may render it less soluble in highly polar environments, indicating that it could exhibit better solubility in organic solvents like ethanol or methanol.
  • Hydrogen Bonding: The ability to form hydrogen bonds can significantly impact solubility, potentially increasing interactions with solvent molecules.

As a result, its solubility can be summarized as follows:

  • More soluble in polar solvents due to the hydroxyl groups.
  • Moderate solubility in less polar solvents.
  • Limited solubility in non-polar solvents.

In practical terms, this specific solubility behavior can affect its utilization in various chemical processes, biological applications, or formulation in pharmaceuticals, making a thorough understanding of its solubility characteristics essential for scientists and engineers.

Interesting facts

Exploring 17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione

This remarkable compound, often referenced for its complex structure and functionality, plays a significant role in the field of organic chemistry and pharmacology. Below are some fascinating insights:

  • Structural Beauty: The compound features an intricate arrangement of rings and substituents which contributes to its unique chemical behavior. It showcases a combination of cyclopenta[a]phenanthrene and keto groups, revealing extensive possibilities for reactivity and application.
  • Pharmacological Potential: Research has indicated that derivatives of this structure might exhibit biological activity, making them candidates for further study in drug development and therapeutic research.
  • Functional Groups: The presence of hydroxyl groups and dione functionality suggests that this compound may engage in various chemical interactions, such as hydrogen bonding and redox reactions. This opens avenues in materials science and organic synthesis.
  • Natural Occurrence: Compounds with similar structures are often found in natural sources, indicating a potential role in biological systems. Understanding this compound could lead to insights into natural product chemistry.

As emphasized by chemists, “The complexity of a compound often leads to a wealth of possibilities.” Thus, the study of 17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione not only satisfies the curiosity of chemists but may also yield significant advancements in medicinal chemistry and synthetic applications.

Synonyms
Betalone
16a-Methyl-11-oxo Prednisolone
Betapred
NSC527579
Deltacortone Beta
17,21-dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
16.beta.-Methylprednisone
17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
DTXSID70859608
AKOS015895270
LS-14958
EN300-296066
Pregna-1,11,20-trione, 17,21-dihydroxy-16.beta.-methyl-
Pregna-1,11,20-trione, 17,21-dihydroxy-16-methyl-, (16.beta.)-
1-hydroxy-1-(2-hydroxyacetyl)-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7,10-dione