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Cortisone

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Identification
Molecular formula
C21H28O5
CAS number
53-06-5
IUPAC name
17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
State
State

Cortisone is a solid at room temperature.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.20
Boiling point (Celsius)
608.10
Boiling point (Kelvin)
881.30
General information
Molecular weight
360.45g/mol
Molar mass
360.4450g/mol
Density
1.3100g/cm3
Appearence

Cortisone typically appears as a white or almost white crystalline powder.

Comment on solubility

Solubility of 17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

The solubility of 17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one (C21H28O5) can be quite fascinating due to the unique characteristics of polycyclic compounds. Solubility is influenced by various factors including molecular structure, polarity, and the presence of functional groups.

Factors Affecting Solubility:

  • Molecular Structure: The complex polycyclic structure of this compound affects how well it interacts with solvents.
  • Polarity: Given that it contains hydroxyl groups (-OH), the compound may exhibit moderate solubility in polar solvents like water.
  • Hydrophobic Regions: The large hydrophobic parts of the molecule could hinder solubility in non-polar solvents.

Generally, it can be expected that:

  • It may display moderate solubility in alcohols and other organic solvents.
  • In water, the solubility might be limited due to its hydrophobic characteristics.

Ultimately, the solubility of this compound could be complex, and specific conditions such as temperature and pH may dramatically change solubility behavior. Understanding these factors is key for applications in pharmaceuticals and chemical industries as solubility plays a critical role in bioavailability, absorption, and formulation of active ingredients.

Interesting facts

Exploring 17-Hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one

17-Hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one is a fascinating compound that falls within the steroid class of organic molecules. Its complex structure hints at a myriad of potential biological activities and applications.

Key Features

  • Steroidal Backbone: This compound features a tetradecahydrocyclopenta[a]phenanthrene structure, which is characteristic of many natural steroids, indicating its potential roles in biological systems.
  • Hydroxyl Group: The presence of a hydroxyl (-OH) group at the 17-position is significant, as hydroxy-steroids often possess enhanced solubility in biological fluids and can participate in various biological pathways.
  • Trimethyl Groups: The three methyl groups contribute to the compound's complex three-dimensional shape, which may affect its binding affinity to biological targets.

Biological Significance

This compound may have implications in pharmacology and biochemistry. Compounds with such structures have been studied for their potential roles in:

  • Hormonal Activity: Many steroids modulate hormonal functions within the body and can affect physiological processes such as metabolism and growth.
  • Therapeutic Uses: Certain derivatives of steroids are employed in various treatments, including anti-inflammatory and cancer therapies.
  • Natural Sources: Understanding compounds like this can help in exploring naturally occurring substances in plants or animals that have similar structures and biological functions.

In summary, the study of 17-hydroxy-2,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one offers a glimpse into the intricate world of compounds that bridge chemistry and biology, presenting opportunities for new discoveries and applications in medicine and biology.

Synonyms
58-19-5
Dihydro-2.alpha.-methyltestosterone
IKXILDNPCZPPRV-UHFFFAOYSA-N
FD22621
Testosterone, 4,5.alpha.-dihydro-2.alpha.-methyl-
17-.beta.-Hydroxy-2-.alpha.-methyl-5-.alpha.-androstan-3-one
2-.alpha.-Methyl-17-.beta.-hydroxy-5-.alpha.-androstan-3-one
(2a,5a,17b)-17-Hydroxy-2-methylandrostan-3-one;17b-Hydroxy-2a-methyl-5a-androstan-3-one;2a-Methyl-17b-hydroxy-5a-androstan-3-one