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Hydrocortisone

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
17-hydroxy-2,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

Hydrocortisone is a solid at room temperature, typically manufactured as a powder for pharmaceutical formulations.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
572.00
Boiling point (Kelvin)
845.15
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.3100g/cm3
Appearence

Hydrocortisone generally appears as a white to practically white, odorless crystalline powder. It is slightly soluble in water but freely soluble in alcohol and chloroform.

Comment on solubility

Solubility of 17-Hydroxy-2,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of 17-hydroxy-2,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one can vary significantly depending on various factors including temperature and the solvent used. Here are some key points to consider:

  • Polarity: This compound, being a steroid derivative, is generally non-polar, which suggests it may have limited solubility in polar solvents such as water.
  • Solvent Systems: It is more likely to dissolve in non-polar or weakly polar organic solvents such as hexane, ethyl acetate, or chloroform.
  • Temperature Effects: As temperature increases, solubility in organic solvents usually increases, allowing for better dissolution of this compound in suitable media.
  • Characterization Methods: Evaluation of solubility is crucial and can be performed using techniques such as UV-Vis spectroscopy or NMR, which help in determining the concentration of the compound in solution.

In summary, while 17-hydroxy-2,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one may exhibit low solubility in polar solvents, it has a greater affinity for non-polar systems. Therefore, selecting the right solvent and conditions is essential for optimizing its solubility for various applications.

Interesting facts

Interesting Facts about 17-hydroxy-2,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This compound, known by its complex name, is a fascinating member of the steroid family. Steroids are organic compounds characterized by a core structure of four fused carbon rings, which are vital in numerous biological processes.

Biological Significance

  • Hormonal Roles: Many steroids, including this compound, may function as precursors in the synthesis of hormones that regulate various physiological activities.
  • Therapeutic Applications: Steroids have been utilized in medicine for their anti-inflammatory and immunosuppressive properties.
  • Reproductive Health: Some structures related to this compound contribute to the development of sex hormones, playing critical roles in reproductive health.

Chemistry Insights

The complex structure of this compound showcases the diversity of carbon-based molecules. With multiple methyl groups (–CH₃), the compound exhibits unique steric properties, influencing its behavior in chemical reactions and biological systems.

Fascinating Characteristics

  • Chirality: The presence of multiple stereocenters in this compound indicates it may exhibit chirality, leading to variations in biological activity and interactions.
  • Metabolic Pathways: Understanding how this compound is synthesized and metabolized can reveal insights into biochemical pathways essential for life.
  • Natural Sources: Many steroids are derived from natural sources, such as plant and animal tissues, which can lead to ecological studies surrounding its presence and function.

In summary, 17-hydroxy-2,13,17-trimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one serves as a good reminder of the intricate relationships between chemical structure and biological function. As a compound studied in laboratory settings, it continues to inspire research in both chemistry and medicine.

Synonyms
NCIOpen2_007429
17-HYDROXY-2,13,17-TRIMETHYL-1,2,6,7,8,9,10,11,12,14,15,16-DODECAHYDRO CYCLOPENTA[A]PHENANTHREN-3-ONE
DB-226167