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Naltrexone

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Identification
Molecular formula
C20H23NO4
CAS number
16590-41-3
IUPAC name
17-methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol
State
State

At room temperature, naltrexone is in the form of a solid powder.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
341.41g/mol
Molar mass
341.4110g/mol
Density
1.4500g/cm3
Appearence

Naltrexone typically appears as a white, crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of 17-methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol

The solubility of the compound 17-methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol can be quite complex due to its intricate molecular structure and the presence of multiple functional groups. Understanding its solubility characteristics is essential for practical applications and can be outlined as follows:

  • Polarity: The polar functional groups, such as the methoxy (-OCH3) and hydroxyl (-OH), typically contribute to solubility in polar solvents like water.
  • Hydrophobic regions: The extensive hydrophobic regions in the structure may limit solubility in aqueous environments, making it better suited to organic solvents.
  • pH Sensitivity: The solubility may vary with pH due to the ability of the hydroxyl group to participate in hydrogen bonding and potentially ionize.
  • Common Solvents: Historically, compounds with similar structures often exhibit solubility in solvents like DMSO, ethanol, or acetonitrile.
  • Temperature Dependence: It has been observed that solubility can also be temperature-dependent, generally increasing with rising temperatures for many organic compounds.

In summary, while the exact solubility data for this specific compound may not be readily available, its solubility can be inferred from its chemical structure and the properties of similar compounds. It is worth noting that “like dissolves like” plays a crucial role in determining solubility, so evaluating the compatibility of solvents with the compound's structure is key for practical uses.

Interesting facts

Interesting Facts about 17-Methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol

This compound is a fascinating example of complex organic chemistry, illustrating how intricate molecular structures can lead to unique properties and potential applications.

Chemical Structure and Features

  • Unique Framework: The name indicates a pentacyclic structure, which means the compound is built around a framework of five interconnected rings. This level of complexity often results in intriguing interactions with biological systems.
  • Functional Groups: The presence of methoxy and hydroxyl groups enhances the molecule's potential reactivity and solubility in various organic solvents.
  • Dioxa and Azapentacyclo: The incorporation of oxygen and nitrogen atoms in the rings suggests that this compound may exhibit unique chemical reactivity, possibly making it a subject of interest in material science and drug development.

Biological and Pharmaceutical Potential

Given its intricate structure, this compound may hold potential in various fields:

  • Medicinal Chemistry: Complex organic compounds like this one often show promising activity against biological targets. Research into their pharmacological properties could lead to new therapies.
  • Natural Product Mimics: Compounds with similar frameworks can be found in nature; mimicking these structures may aid in developing drugs that harness natural mechanisms.

Research and Development

The study of such compounds often leads to:

  • New Synthetic Methods: Chemists may explore innovative synthetic pathways to produce this and similar compounds efficiently.
  • Evaluation of Stability: Understanding the stability and degradation pathways can be crucial for developing effective formulations.

In summary, 17-methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol is a remarkable compound that embodies the complexity and beauty of organic chemistry. Each aspect of its structure presents opportunities for further inquiry and application in science.

Synonyms
d-Bulbocapnine
5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinolin-12-ol, 6,7,7a,8-tetrahydro-11-methoxy-7-methyl-
72002-80-3
Bulbokapnin
Oprea1_003816
SCHEMBL11253583
ACon1_002350
DTXSID50871626
LODGIKWNLDQZBM-UHFFFAOYSA-N
NCGC00169929-01
BRD-A35379089-001-01-6
6a.alpha.-Aporphin-11-ol, 10-methoxy-1,2-(methylenedioxy)-
11-Methoxy-7-methyl-6,7,7a,8-tetrahydro-2H,5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinolin-12-ol
11-Methoxy-7-methyl-6,7,7a,8-tetrahydro-5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinolin-12-ol, (S)-
17-methoxy-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.0(2),?.0?,(2)?.0(1)?,(1)?]icosa-1(20),2(6),7,14(19),15,17-hexaen-18-ol