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Sertraline

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Identification
Molecular formula
C17H22ClN
CAS number
79617-96-2
IUPAC name
1,7,7-trimethyl-N-(p-tolylmethyl)norbornan-2-amine
State
State
At room temperature, Sertraline is in a solid state, typically handled as a hydrochloride salt in pharmaceutical formulations.
Melting point (Celsius)
246.00
Melting point (Kelvin)
519.15
Boiling point (Celsius)
540.80
Boiling point (Kelvin)
813.95
General information
Molecular weight
213.37g/mol
Molar mass
213.3660g/mol
Density
1.1865g/cm3
Appearence

Sertraline appears as a white, crystalline powder. It is typically odorless and can be dissolved in ethanol, methanol, and dimethyl sulfoxide. It is usually formulated in its hydrochloride salt form for use in pharmaceutical applications.

Comment on solubility

Solubility of 1,7,7-Trimethyl-N-(p-tolylmethyl)norbornan-2-amine

The solubility of 1,7,7-trimethyl-N-(p-tolylmethyl)norbornan-2-amine is a topic of interest due to its unique structural features. While comprehensive data might be scarce, several key points can be considered:

  • Polarity: The presence of the amine functional group suggests that the compound may possess some polar characteristics. However, the bulky hydrophobic norbornane structure and the p-tolylmethyl group may hinder solubility in water.
  • Solvent Compatibility: Expected solubility in organic solvents:
    • Chloroform
    • Ethyl acetate
    • Acetone
  • Water Solubility: It is likely to be insoluble or only sparingly soluble in water due to its hydrophobic nature, influenced by the bulky groups.

In conclusion, while specific solubility values may vary, it can be asserted that 1,7,7-trimethyl-N-(p-tolylmethyl)norbornan-2-amine is better equipped to dissolve in non-polar or slightly polar organic solvents. The interaction of its molecular structure with solvent properties is a fascinating area for further exploration.

Interesting facts

Interesting Facts about 1,7,7-Trimethyl-N-(p-tolylmethyl)norbornan-2-amine

1,7,7-Trimethyl-N-(p-tolylmethyl)norbornan-2-amine, often referred to for its structural complexity and functional applications, is a compound of notable interest in the field of organic chemistry. Here are some key details that highlight its significance:

  • Structural Attributes: This compound features a bicyclic structure typical of norbornane derivatives, providing unique steric and electronic properties that can influence its reactivity and interactions.
  • Functional Groups: The presence of both a dimethylamine and a p-tolylmethyl group introduces significant variations in electronic distribution, which can lead to diverse applications in pharmaceuticals and agrochemicals.
  • Synthetic Applications: The complexity of this compound makes it a prime candidate in synthetic organic chemistry. Its unique architecture can serve as a versatile scaffold for creating various bioactive molecules.
  • Catalytic Properties: Some derivatives of compounds with amine functionalities have shown promise in catalysis, promoting reactions like amination or hydrogenation, which are vital in industrial applications.
  • Biological Relevance: The modifications of amine groups in nitrogen-containing heterocycles are often correlated with enhanced biological activities, making this compound a molecule of interest for drug design and discovery.

Indeed, 1,7,7-trimethyl-N-(p-tolylmethyl)norbornan-2-amine exemplifies how compact structures can hold valuable potential in both theoretical studies and practical applications. As we further explore this compound, we may unlock new avenues for innovation in medicinal chemistry.

Synonyms
AKOS008990592