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Clomiphene

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Identification
Molecular formula
C28H32ClNO2
CAS number
911-45-5
IUPAC name
[(17R)-17-acetyl-6-chloro-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
State
State
Solid at room temperature.
Melting point (Celsius)
116.00
Melting point (Kelvin)
389.15
Boiling point (Celsius)
454.20
Boiling point (Kelvin)
727.40
General information
Molecular weight
405.97g/mol
Molar mass
403.9650g/mol
Density
1.2405g/cm3
Appearence

This compound typically appears as a white to off-white crystalline powder. It is insoluble in water but soluble in organic solvents such as ethanol and chloroform.

Comment on solubility

Solubility of [(17R)-17-acetyl-6-chloro-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate

The solubility of a compound like [(17R)-17-acetyl-6-chloro-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate can be influenced by several factors due to its complex structure:

  • Polarity: Generally, compounds that contain functional groups such as esters and ketones exhibit variability in solubility depending on the presence of polar or non-polar characteristics.
  • Solvent Nature: The choice of solvent is crucial. For instance, non-polar solvents like hexane may struggle to dissolve this compound, whereas polar solvents such as ethanol or methanol may improve solubility.
  • Temperature: Increased temperatures can enhance solubility for many organic compounds, affecting whether [(17R)-17-acetyl-6-chloro-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate dissolves more readily.
  • pH Levels: The acidity or basicity of the solution can also play a role in solubility, particularly for compounds that have functional groups sensitive to pH changes.

While the specific solubility data for this compound may not be readily available, understanding that it may exhibit limited solubility in water and potentially higher solubility in organic solvents can provide a foundational perspective for handling it in various applications. It's essential to experiment with different solvents to ascertain the best possible conditions for achieving optimal dissolution.

Interesting facts

Interesting Facts about (17R)-17-acetyl-6-chloro-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl Acetate

This complex organic compound represents a fascinating intersection of organic chemistry and medicinal applications. Its structure showcases a unique arrangement of fused rings, which are characteristic of steroids, revealing insights into its potential biological functions.

Key Characteristics:

  • Synthetic Origins: This compound is often synthesized in a laboratory setting, showcasing the intricate methods of organic synthesis. Chemists utilize various reactions, including acetylation and chlorination, to achieve its unique structure.
  • Biological Relevance: Due to its steroid-like framework, research suggests potential applications in fields such as pharmacology, particularly in the development of anti-inflammatory and hormonal agents. Such compounds often interact with biological receptors, playing critical roles in biochemical pathways.
  • Chirality: The 'R' configuration at the 17 position indicates chirality, which can significantly impact the compound’s biological activity. Isomers can exhibit drastically different effects in biological systems, making stereochemistry a key area of focus in drug design.
  • Analytical Techniques: Scientists often employ advanced analytical techniques such as NMR (Nuclear Magnetic Resonance) and mass spectrometry to study the compound’s structure and purity, enabling deeper insights into its properties and reactivity.

In conclusion, the exploration of (17R)-17-acetyl-6-chloro-13-methyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl acetate continues to broaden our understanding of organic compounds and their applications in science and medicine. Each new study contributes valuable data, potentially leading to therapeutic advancements.