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Fluocinolone acetonide

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Identification
Molecular formula
C24H30F06
CAS number
67-73-2
IUPAC name
[(17R)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] pentanoate
State
State
Fluocinolone acetonide is typically found as a solid at room temperature.
Melting point (Celsius)
271.00
Melting point (Kelvin)
544.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
452.49g/mol
Molar mass
452.4930g/mol
Density
1.3600g/cm3
Appearence
Fluocinolone acetonide appears as a white to creamy-white, crystalline powder.
Comment on solubility

Solubility of [(17R)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[[a]](https://example.com/phenanthren-17-yl) pentanoate

The solubility of the compound [(17R)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[[a]](https://example.com/phenanthren-17-yl) pentanoate] tends to be a challenging aspect due to its complex molecular structure.

In general, the solubility of organic compounds such as this one can be influenced by various factors:

  • Molecular Structure: The presence of multiple functional groups like hydroxyl and fluorine can enhance hydrogen bonding, potentially increasing solubility in polar solvents.
  • Polarity: As a compound containing significant polar components, it may exhibit greater solubility in polar solvents (e.g., water, methanol) compared to non-polar solvents.
  • Temperature: Solubility typically increases with temperature; thus, heating the solvent may enhance the dissolution process.
  • pH Influence: Depending on the pH of the solution, the ionization of functional groups can further influence solubility characteristics.

It's essential to note that solubility can be quite variable and may require empirical testing to obtain precise measurements for this complex compound. As the saying goes, “a compound is only as soluble as its environment.” Therefore, for precise applications, experimental determination of solubility in various media is crucial.

Interesting facts

Interesting Facts about [(17R)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] pentanoate

This compound, a complex derivative of steroids, presents a fascinating study for chemists and biologists alike due to its multifaceted structure and potential applications in medicine. Its intricate formulation is a testament to the beauty of organic chemistry, particularly in the modification of naturally occurring steroidal frameworks.

Key Features

  • Structural Diversity: The presence of multiple functional groups such as hydroxy and fluoro makes this compound a subject of interest for synthetic organic chemistry.
  • Biological Activity: Compounds like this have been studied for their potential pharmaceutical effects, particularly in relation to hormonal activity and anti-inflammatory properties.
  • Synthetic Challenges: The synthesis of such a complex molecule often involves multistep reactions, which can showcase advanced techniques such as asymmetric synthesis and selective functionalization.

As with many steroid derivatives, the challenge lies not just in creating the molecule, but also in understanding its mechanism of action once synthesized. The introduction of fluorine atoms, for example, can significantly alter the compound's potency and bioavailability, and this has prompted extensive research.

Noteworthy Research Insights

  • The pharmacological implications of modified steroids have led to their exploration in treatments for conditions such as cancer and autoimmune diseases.
  • Environmental impact studies may investigate how these compounds behave in biological systems and their potential to bioaccumulate.

In conclusion, the investigation of [(17R)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] pentanoate not only deepens our understanding of steroid chemistry but also opens doors to innovative therapeutic avenues. This compound exemplifies the intersection of structural complexity and biological relevance, making it an intriguing subject within the realm of chemical sciences.

Synonyms
DTXSID60945948
6-Fluoro-11,21-dihydroxy-3,20-dioxopregna-1,4-dien-17-yl pentanoate