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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol
State
State

Estradiol is typically found as a solid at room temperature.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1700g/cm3
Appearence

Estradiol appears as a colorless crystalline solid. It is often encountered as a fine white powder when used in medications and formulations.

Comment on solubility

Solubility of (17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol

When considering the solubility of (17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol, several key factors come into play. Solubility can be influenced by the compound's structure, functional groups, and the polarity of the solvent. In this case, we can outline a few points regarding its solubility behavior:

  • Polarity: The presence of hydroxyl groups (-OH) typically enhances solubility in polar solvents such as water.
  • Hydrophobic Character: As a hydrocarbon structure, the compound may exhibit hydrophobic tendencies, leading to decreased solubility in water.
  • Solvent Compatibility: It may be more soluble in organic solvents like ethanol or dimethyl sulfoxide (DMSO) that can interact favorably with both the polar and non-polar parts of the molecule.
  • Temperature Effects: The solubility might increase with temperature, particularly in organic solvents, due to enhanced molecular motion.

In conclusion, while (17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol may exhibit some solubility in polar solvents, it is likely to have better solubility in non-polar or weakly polar organic solvents. Understanding its solubility profile is crucial for practical applications in fields such as pharmaceuticals and biochemistry, where the ability to dissolve a compound can affect its bioavailability and behavior in living systems.

Interesting facts

Interesting Facts about (17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol

(17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol is a fascinating compound that has piqued the interest of researchers in the fields of organic chemistry and medicinal research. Here are some noteworthy aspects:

  • Stereochemistry: This compound's specific stereochemical configuration (17S) plays a critical role in its biological activity. The chirality can significantly affect how the compound interacts with biological systems, making stereochemistry a vital aspect in drug development.
  • Natural Product Analog: Compounds of this class are often related to natural products, which can lead to insights into their biological functions and potential therapeutic effects. Studying such analogs may unveil new pathways for drug discovery.
  • Potential Applications: With its unique structure, this compound may offer a range of applications, particularly in medicinal chemistry. Research continues in exploring its potential as an anti-cancer agent or other therapeutic roles.
  • Complex Synthesis: The synthesis of (17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol represents a challenge for chemists, requiring advanced techniques and strategies to construct its intricate structure.
  • Structural Insights: Understanding the three-dimensional arrangement of atoms in this compound is crucial for predicting its chemical reactivity and interactions with biological molecules, opening doors to structured design in pharmaceutical chemistry.

This compound exemplifies how complex chemical structures can lead to significant implications in the realm of science and medicine. As research evolves, the exploration of compounds like (17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol continues to yield exciting findings that could reshape our understanding and application of organic compounds.

Synonyms
SCHEMBL14093746