Skip to main content

Estradiol

ADVERTISEMENT
Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol
State
State

At room temperature, estradiol is solid. It is commonly used in pharmaceutical formulations as an estrogen hormone replacement.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
542.00
Boiling point (Kelvin)
815.15
General information
Molecular weight
272.39g/mol
Molar mass
272.3880g/mol
Density
1.1650g/cm3
Appearence

Estradiol appears as a white or creamy white, crystalline powder. It is practically odorless and tasteless.

Comment on solubility

Solubility of (17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol

Understanding the solubility of (17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol is crucial for its applications and interactions within various environments. The solubility of this compound can be influenced by several factors:

  • Polarity: The hydroxyl (-OH) groups in the structure suggest that this compound could exhibit some level of polarity, which could enhance its solubility in polar solvents like water.
  • Hydrophobic character: Given its extensive hydrocarbon framework, the compound is likely to possess hydrophobic properties that may reduce its solubility in aqueous solutions.
  • Temperature dependence: Solubility is often temperature-dependent; thus, increased temperatures may improve solubility in specific solvents.
  • Interactions with solvents: The choice of solvent is crucial. For example, it may be more soluble in organic solvents such as ethanol or DMSO due to favorable interactions between the solvent and the compound.

While there is limited specific literature detailing the exact solubility profile of this intricate compound, it would be reasonable to consider that:

  • It may display variable solubility contingent upon the solvent used.
  • In the presence of strong polar solvents, solubility may improve due to the formation of hydrogen bonds with the -OH groups.
  • However, in non-polar solvents, its solubility might be considerably diminished.

In summary, the solubility characteristics of (17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol are complex and warrant further investigation to fully elucidate its behavior in various chemical environments.

Interesting facts

Interesting Facts about (17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol

This compound, known for its complex structure, falls under the category of polycyclic compounds. Its intricate arrangement of carbon atoms gives rise to unique properties and functionalities that capture the interest of chemists and researchers alike.

Chemical Structure and Properties

The chemical structure showcases a fused ring system, which is characteristic of many organic compounds. Here are some noteworthy aspects:

  • Polycyclic Nature: Its multiple interconnected rings highlight the compound's stability and reflect the intricate nature of organic synthesis.
  • Stereochemistry: The designation (17S) indicates a specific stereochemical configuration, which is crucial in determining the compound's biological activity and interaction with other molecules.

Biological Relevance

This compound might also be of interest due to its potential biological applications. Compounds with similar structures have been studied for:

  • **Medicinal Chemistry:** There is ongoing research into how these types of compounds can serve as lead compounds in drug development.
  • **Hormonal Activity:** Some polycyclic compounds have been linked to hormonal regulation, making them fascinating subjects in the study of endocrine disruptors.

Research Implications

The study of (17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol serves as an example of how organic chemistry intersects with multiple disciplines:

  • Pharmacology: Understanding its structure can unlock insights into its mechanism of action within biological systems.
  • Environmental Science: Investigating polycyclic compounds can help comprehend their role in both natural and polluted environments.

In conclusion, the rich structural and functional characteristics of (17S)-13-methyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol not only adds depth to the field of chemistry but also opens avenues for impactful discoveries in medicine and environmental science.