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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-1,3,17-triol
State
State

In its pure form, estradiol is a solid at room temperature, typically seen as a finely divided crystalline powder.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
440.50
Boiling point (Kelvin)
713.70
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.1698g/cm3
Appearence

Estradiol appears as a white or almost white crystalline powder. It is odorless and is known for its ability to absorb moisture. The compound can have a slightly creamy appearance when in its powder form.

Comment on solubility

Solubility of (17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-1,3,17-triol

The solubility of (17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-1,3,17-triol can be quite complex due to its unique structural characteristics. As a high molecular weight compound with multiple rings, its solubility is likely to be affected by several factors:

  • Polarity: The presence of hydroxyl groups (-OH) suggests that the compound may exhibit some degree of polarity, potentially leading to solubility in polar solvents, such as water or alcohols.
  • Hydrophobic Interactions: The extensive hydrocarbon backbone might lead to values of low solubility in water, favoring solubility in non-polar solvents like hexane or toluene.
  • Temperature: Increased temperature could enhance solubility, particularly in organic solvents, as the kinetic energy enables better interactions between solute and solvent molecules.
  • Concentration: At higher concentrations, the solubility may also vary significantly, potentially leading to saturation and precipitation.

In general, it’s important to conduct solubility tests under controlled conditions to gather precise data. As with many complex organic compounds, it can be summarized that the solubility is heavily influenced by the balance of polar and non-polar characteristics as well as environmental factors. Always remember the adage: "Like dissolves like." Thus, knowing the nature of the solvent is crucial in anticipating the solubility behavior of this compound.

Interesting facts

Exploring (17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-Decahydrocyclopenta[a]phenanthrene-1,3,17-Triol

(17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-1,3,17-triol is a fascinating chemical compound that falls within the class of polycyclic compounds. Its intricate molecular structure makes it a noteworthy subject of study in organic chemistry and biochemistry.

Key Features

  • Steroidal Structure: This compound has a steroid-like backbone due to its multiple fused rings, making it interesting for studying steroid hormones and their analogs.
  • Natural Occurrence: Several compounds with similar structures are found naturally in various biological systems, including plants and animals.
  • Biological Significance: It has potential implications in medical research, particularly in the study of metabolic pathways and signaling mechanisms.

The complexity of its structure leads to a variety of potential interactions with biological systems. As a chemistry student or researcher, considering its stereochemistry is crucial, as the specific arrangement of its atoms can significantly influence its biological activity.

Research Opportunities

This compound opens avenues for:

  • Drug Design: Investigating how slight modifications can enhance therapeutic efficacy.
  • Natural Product Synthesis: Understanding how to synthesize this compound can provide insights into producing other bioactive molecules.
  • Environment Interaction: Studying its environmental stability and how it interacts with other compounds can shed light on ecological impacts.

In conclusion, (17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-1,3,17-triol, with its unique structural attributes and potential applications, represents a rich area for scientific exploration, bridging organic synthesis, pharmacology, and biology.

Synonyms
Estra-1(10),2,4-triene-1,3,17-triol
DTXSID30961731
4147-05-1
AKOS032962499