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Norethisterone

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Identification
Molecular formula
C20H26O2
CAS number
68-22-4
IUPAC name
(17S)-17-buta-1,3-diynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, norethisterone is in a solid state. It is commonly found in medicinal or pharmaceutical preparations as oral tablets or capsules.

Melting point (Celsius)
203.15
Melting point (Kelvin)
476.30
Boiling point (Celsius)
372.15
Boiling point (Kelvin)
645.15
General information
Molecular weight
298.42g/mol
Molar mass
298.4190g/mol
Density
1.1560g/cm3
Appearence

Norethisterone typically appears as a white or slightly yellow crystalline powder. It has no distinct odor and is generally used in its powdered form in pharmaceutical applications.

Comment on solubility

Solubility Characteristics

The solubility of the compound (17S)-17-buta-1,3-diynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one, can be quite complex due to its unique molecular structure. Understanding its solubility profile is essential for practical applications in various fields.

Factors Influencing Solubility

Several key factors generally play a role in determining the solubility of a compound:

  • Molecular Structure: Highly hydrophobic groups may lead to low water solubility.
  • Polarity: A more polar molecule tends to dissolve better in polar solvents (e.g., water).
  • Temperature: Increased temperature can enhance solubility for many compounds.
  • pH Levels: The solubility may vary with changes in pH, particularly for compounds with functional groups that can ionize.

Solubility Insights

For (17S)-17-buta-1,3-diynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one, it is anticipated that:

  • The compound may exhibit low solubility in water, attributed to its large hydrophobic nature and extensive aliphatic and aromatic components.
  • Ionic or polar solvents might increase solubility due to potential interactions with functional groups.

While specific experimental data is essential to confirm these behaviors, it is crucial to explore suitable solvents for its application. As the saying goes, "Like dissolves like," indicating that understanding the nature of the solvent can lead to more effective utilization of this compound.

Interesting facts

Exploring (17S)-17-buta-1,3-diynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This intriguing compound, known for its complex structure, belongs to the family of polycyclic compounds that exhibit unique chemical properties and potential biological activities. Here are several noteworthy aspects:

  • Structural Complexity: The compound features a multi-ring system typical of steroid-like structures. This complexity can make it a fascinating subject for studies in structural chemistry and molecular modeling.
  • Potential Biological Activity: Compounds with similar structures have been investigated for their roles in biological systems. They could manifest interesting pharmacological properties such as anti-inflammatory or anticancer activities, although extensive research is required to substantiate these claims.
  • Synthetic Challenges: The synthesis of such polycyclic compounds often involves intricate reactions and multistep processes. This makes them a great example for chemists to discuss mechanisms of organic reactions and the importance of reaction conditions.
  • Practical Applications: Beyond theoretical exploration, compounds in this class might be utilized in drug design or the development of new materials. Their unique configurations can lead to novel interactions with biological targets.
  • Interest in Dehydro-Compounds: The presence of diynyl groups contributes to the compound's reactivity. Studying the interactions of such functional groups can enhance our understanding of alkyne chemistry, which remains significant in organic synthesis.

Quotes from chemists often highlight the beauty of complexity in organic molecules: "In the intricate dance of atoms, lies the key to unlocking nature's treasures." This compound serves as a compelling example of how complexity can inspire innovation in the fields of chemistry and pharmacology.

In conclusion, (17S)-17-buta-1,3-diynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one provides a rich canvas for chemists to explore the interplay of structure, synthesis, and biological activity in the fascinating realm of organic chemistry.