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Levonorgestrel

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Identification
Molecular formula
C21H28O2
CAS number
797-63-7
IUPAC name
(17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

Levonorgestrel exists as a solid at room temperature.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.15
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.15
General information
Molecular weight
312.46g/mol
Molar mass
312.4480g/mol
Density
1.1700g/cm3
Appearence

Levonorgestrel is a white or almost white crystalline powder. It is practically insoluble in water, sparingly soluble in alcohol, and freely soluble in chloroform.

Comment on solubility

Solubility of (17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of (17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one can be influenced by several factors, primarily its structure and the presence of functional groups. Here are some critical points to consider:

  • Polarity: The presence of hydroxyl (-OH) groups suggests some degree of polarity, which typically increases solubility in polar solvents such as water.
  • Hydrophobic Regions: Due to the complex hydrocarbon structure, there are likely hydrophobic sections that could limit solubility in polar solvents and favor solubility in non-polar solvents.
  • Solvent Compatibility: It is essential to test solubility in various organic solvents like ethanol, methanol, or dichloromethane to determine the optimal medium for dissolution.
  • Concentration Effects: The solubility may vary significantly with concentration; hence, examining the compound at different concentrations may yield valuable insights.

In conclusion, while certain predictions can be made based on the structure of (17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one, definitive solubility results can only be established through empirical testing. Testing under different conditions is crucial, as the statement goes: “The theory of solubility is often challenged by practical outcomes.”

Interesting facts

Interesting Facts about (17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This compound, often referred to by its abbreviated name, has garnered attention within the fields of medicinal chemistry and pharmacology due to its intriguing structural composition and potential biological activities.

Key Characteristics:

  • Structural Complexity: The compound features a unique dodecahydrocyclopenta[a]phenanthren skeleton, which contributes to its interesting chemical properties.
  • Stereochemistry: The specific configuration of the 17-hydroxy group on the molecule plays a critical role in its reactivity and interaction with biological targets.
  • Biological Significance: This compound is associated with various therapeutic potentials, particularly in the field of oncology and hormone-related therapies.

Potential Applications:

Researchers are exploring several applications for this compound, including but not limited to:

  • Hormonal regulation: Its structure suggests it may interact with hormone receptors.
  • Anti-cancer properties: Some derivatives of similar structures have shown promise in inhibiting tumor growth.
  • Neuroprotective effects: Compounds with similar cylic frameworks have been studied for their potential to protect against neurodegenerative diseases.

A Remarkable Quote:

As a noted chemist once said, "The structure of a compound often predicts its destiny." This compound exemplifies that idea, where its complexities may unveil novel therapeutic pathways.

In conclusion, (17S)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one not only inspires curiosity among chemists but also holds great promise in future medicinal research.