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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(17S)-17-hydroxy-13,17-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
State
State

At room temperature, estrone is in a solid state, appearing as a white crystalline powder.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
361.00
Boiling point (Kelvin)
634.15
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of (17S)-17-hydroxy-13,17-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of (17S)-17-hydroxy-13,17-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one is an intriguing subject that reflects its chemical structure and properties. Generally, the solubility of organic compounds can be influenced by their polarity, molecular weight, and overall structure. Here are some key points to consider:

  • Structural Influence: The presence of multiple ring structures may decrease solubility in polar solvents due to a lack of functional groups that can engage in hydrogen bonding.
  • Solvent Considerations: Likely to be more soluble in organic solvents such as ethanol, acetone, or chloroform compared to water.
  • Hydrophobic Nature: Its bulky structure suggests a hydrophobic characteristic, leading to low solubility in aqueous solutions.

In summary, the solubility of this compound can be summarized as being relatively low in water but potentially higher in non-polar or slightly polar organic solvents, making it essential to consider the solvent choice in any experimental context.


Interesting facts

Interesting Facts about (17S)-17-hydroxy-13,17-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one

This intriguing compound, commonly recognized in the realm of organic chemistry and biochemistry, is noteworthy for its complex structure and unique properties. Here are some interesting aspects to consider:

  • Synthetic Importance: This compound is a significant precursor in the synthesis of various steroids, showcasing its utility as a building block in pharmaceutical applications.
  • Biological Activity: Compounds of this class often exhibit a range of biological activities, including hormonal and therapeutic effects, making them valuable in medicinal chemistry.
  • Chirality: The “17S” designation indicates that this molecule possesses chirality, which can influence its biological interactions and pharmacokinetic properties.
  • Structural Complexity: With its intricate ring structure, the compound is a part of the larger family of polycyclic compounds, known for their rich chemical behavior.
  • Potential Research Applications: Researchers often explore the potential of such compounds in cancer treatment and other diseases, given their steroidal nature.

As one delves deeper into the study of this compound, it becomes clear that its multifaceted nature presents an exciting area for ongoing research and exploration.

In the words of chemist George A. Olah, "The complexity of organic compounds embodies the beauty of chemistry." This truism holds especially true for (17S)-17-hydroxy-13,17-dimethyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one, exemplifying the intricate relationships between structure and function in organic molecules.

Synonyms
CCG-248771