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Estriol

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Identification
Molecular formula
C18H24O3
CAS number
50-27-1
IUPAC name
(17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol
State
State

Estriol is a solid at room temperature.

Melting point (Celsius)
282.00
Melting point (Kelvin)
555.20
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
288.38g/mol
Molar mass
288.3810g/mol
Density
1.2200g/cm3
Appearence

Estriol is typically a white or off-white crystalline powder. It is often characterized by its fine, powdery texture and is odorless.

Comment on solubility

Solubility of (17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

The solubility of (17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol is influenced by several factors including its molecular structure and functional groups. Here are some key points to consider:

  • Polar vs Non-Polar: The presence of the methoxy group introduces a polar functional element, which may enhance solubility in polar solvents.
  • Hydrophobic Regions: The extensive hydrocarbon framework contributes to a considerable hydrophobic character, potentially limiting solubility in water.
  • Compatible Solvents: It is likely to be more soluble in apolar solvents like hexane or chloroform.
  • Temperature Factor: Solubility may increase with temperature, as higher energies can disrupt intermolecular interactions.
  • Hydrogen Bonding: Intermolecular hydrogen bonding may also affect solubility, particularly in more polar environments.

In conclusion, while the (17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol exhibits some degree of solubility in polar solvents due to the methoxy group, its overall solubility can be somewhat limited by its hydrophobic characteristics. Therefore, understanding the surrounding environment and choosing the appropriate solvent is key to effectively dissolving this compound.

Interesting facts

Interesting Facts about (17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

(17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol is a fascinating compound with notable biological and chemical properties. Here are some key insights:

  • Natural Origin: This compound is frequently studied in the context of natural products, appearing in certain plant species and fungi, which makes it of interest in both chemistry and pharmacology.
  • Steroid Activity: Its structure suggests possible steroidal activity, which has raised interest in its potential hormonal effects and biological activity.
  • Analytical Techniques: The isolation and characterization of this compound often involve advanced analytical techniques such as NMR (Nuclear Magnetic Resonance) and mass spectrometry, allowing scientists to elucidate its complex structure.
  • Applications in Medicine: Compounds with similar structures are being studied for their potential applications in treating various diseases, particularly hormonal disorders and certain types of cancers.
  • Chirality: The compound possesses chirality, indicated by the (17S) designation, which can lead to different biological activities depending on the stereochemistry, a critical aspect for drug design.
  • Research Significance: Ongoing research into compounds like this one continues to shed light on the relationship between structure and function, influencing new synthetic strategies in organic chemistry.

This compound exemplifies the intricate connections between molecular structure and biological function, highlighting its significance in the interdisciplinary fields of chemistry and biomedicine. As research progresses, the importance of (17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol may become even more pronounced, shaping the future of therapeutic development.

Synonyms
SCHEMBL15263441