Skip to main content

Estradiol

ADVERTISEMENT
Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol
State
State

At room temperature, estradiol is a solid. It is primarily used in pharmaceutical formulations and is handled as a dry powder.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1639g/cm3
Appearence

Estradiol appears as a white or almost white crystalline powder. It is practically odorless and is typically used in a finely ground form for pharmaceutical applications.

Comment on solubility

Solubility of (17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

The solubility of (17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol plays a critical role in its chemical behavior and potential applications. Understanding the solubility characteristics can be essential for various fields, particularly in pharmaceuticals and environmental science. Here are some key points regarding its solubility:

  • Polarity: The presence of the hydroxyl (-OH) group generally contributes to increased solubility in polar solvents such as water. However, the bulkiness of the molecule may hinder its overall solubility.
  • Solvent Compatibility: This compound may show different solubility profiles in various solvents:
    • Highly soluble: Alcohols and aromatic solvents
    • Poorly soluble: Non-polar solvents
  • Temperature Influence: As with many organic compounds, solubility can increase with temperature. It is often advantageous to dissolve compounds in warm solvents to enhance solvation.
  • Salt Formation: The potential for forming salts with acids or bases may also affect solubility properties, particularly in biological systems.

In conclusion, while the solubility of (17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol can be influenced by numerous factors, careful evaluation of its solubility in various media is essential for understanding its practical uses and interactions. As the saying goes, "Like dissolves like," so selecting the appropriate solvent is key in achieving optimal results.

Interesting facts

Interesting Facts About (17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

(17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol is a fascinating compound with significant implications in various scientific fields. Here are some intriguing aspects of this complex molecule:

  • Steroidal Structure: This compound possesses a steroid-like structure, which is often associated with various biological activities. Its arrangement allows for specific interactions with biological targets, making it a subject of interest in pharmacology.
  • Natural Occurrence: The compound's structural elements resemble those found in certain natural products, including hormones and alkaloids, which are crucial in numerous biological processes.
  • Potential Sources: Researchers have identified similar compounds within plant species, particularly those used in traditional medicine. Exploring these natural sources can unveil new therapeutic applications.
  • Conformational Flexibility: The multi-ring structure allows for several conformations, influencing the compound's interaction with enzymes and receptors. This flexibility is critical in drug design as it may determine efficacy and specificity.
  • Importance in Synthesis: The complexity of this molecule presents challenges and opportunities in synthetic organic chemistry, providing a testing ground for innovative strategies in creating similar compounds.

In summary, (17S)-3-methoxy-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol embodies the intricate interconnectedness of chemistry and biology. It highlights the ongoing quest for new pharmaceuticals derived from natural compounds, showcasing the potential for breakthroughs in medicine and therapeutics.

Synonyms
DTXSID50963954
4787-75-1
1-Methoxy-4,9-cyclo-9,10-secoandrosta-1,3,5(10)-trien-17-ol