Fluoroestradiol | Solubility of Things

Identification

Molecular formula

C₁₈H₂₃FO₂

CAS number

66700-62-1

IUPAC name

(17S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

State

At room temperature, fluoroestradiol is in a solid state, specifically as crystalline powder.

Melting point (Celsius)

191.00

Melting point (Kelvin)

464.00

Boiling point (Celsius)

467.50

Boiling point (Kelvin)

740.70

General information

Molecular weight

280.38g/mol

Molar mass

280.3580g/mol

Density

1.2700g/cm³

Appearence

Fluoroestradiol typically appears as a white to off-white crystalline powder. Its appearance is homogeneous without visible impurities.

Comment on solubility

Solubility of (17S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of (17S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol can depend on various factors such as temperature, pH, and the solvent used. Generally, this compound may exhibit:

Limited solubility in water: Due to its hydrophobic nature, the compound is likely to be poorly soluble in aqueous environments.
Enhanced solubility in organic solvents: Compounds with similar structures often display better solubility in non-polar solvents like hexane or chloroform.
Temperature dependency: Increased temperature may improve solubility in organic solvents, making the compound more bioavailable.
pH effects: Depending on the functional groups, altering the pH of the solution might enhance solubility by protonation or deprotonation.

In conclusion, while the exact solubility parameters of this specific compound may vary, it is essential to consider these factors when assessing its solubility in different solvents. As always, experimental determination is key to establishing precise solubility data.

Interesting facts

Interesting Facts about (17S)-4-Fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

This fascinating compound, known for its unique structure and properties, encompasses some interesting aspects that are quite significant for both scientific research and potential applications:

Stereochemistry: The compound features specific stereochemical configurations that play a crucial role in its biological activity. The designation (17S) indicates the specific orientation of its atoms, which can have substantial effects on its reactivity and interactions with biological macromolecules.
Fluorine Substitution: The presence of fluorine is notable. Fluorine atoms can enhance the metabolic stability of organic molecules and often contribute to increased potency in drug design due to their electronegativity, which alters chemical properties.
Polycyclic Structure: This compound belongs to the polycyclic compound family, containing fused ring systems. Such structures are commonly found in many natural products and pharmaceuticals, often influencing their efficacy and biological roles.
Potential Therapeutic Applications: Compounds with a similar structure have been investigated for their potential as drug candidates. The structural similarities to certain steroids and hormones could suggest possible roles in modulating hormonal activities.
Research Opportunities: The intricate structure invites numerous research opportunities in areas such as organic synthesis, drug development, and materials science. Understanding how these chemical frameworks behave can lead to breakthroughs in various fields.

In summary, the compound (17S)-4-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol is not just another chemical entity; it is a gateway to understanding complex interactions in chemistry, biology, and medicine.