Skip to main content

Rapamycin

ADVERTISEMENT
Identification
Molecular formula
C51H79NO13
CAS number
53123-88-9
IUPAC name
18-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-19-vinyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-4,6,8,15-tetraen-14-one
State
State

At room temperature, rapamycin is encountered as a solid. It is usually handled in powder form under laboratory conditions.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.15
General information
Molecular weight
914.17g/mol
Molar mass
914.1720g/mol
Density
1.1683g/cm3
Appearence

Rapamycin is a white to off-white solid. It is typically observed in crystalline or amorphous powder form. The compound is sensitive to light and is usually stored under inert gas in dark conditions to prevent degradation.

Comment on solubility

Solubility Characteristics

The compound 18-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-19-vinyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-4,6,8,15-tetraen-14-one (C51H79NO13) exhibits complex solubility behavior due to its intricate molecular structure. The presence of multiple hydroxyl groups and the unique connectivity of the compound plays a significant role in its interaction with solvents. Here are some key points regarding its solubility:

  • Polar Solvents: The numerous hydroxyl (–OH) groups likely enhance solubility in polar solvents such as water and methanol, as hydrogen bonding can occur.
  • Non-Polar Solvents: Given its extensive carbon framework, the compound may also show some degree of solubility in non-polar organic solvents, although to a lesser extent.
  • Temperature Influence: Solubility can increase with temperature, making it crucial to consider temperature conditions when dissolving this compound.
  • Concentration Dependent: At higher concentrations, the solubility may be affected by intermolecular interactions leading to precipitation or gelation.

In summary, the solubility of this compound is dictated by a delicate balance between its polar and non-polar regions, making it versatile in various solvent systems. As with many complex organic compounds, experimental solubility studies are essential for accurately understanding its behavior in solution.

Interesting facts

Interesting Facts about 18-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-19-vinyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-4,6,8,15-tetraen-14-one

The compound 18-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-19-vinyl-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-4,6,8,15-tetraen-14-one is a complex organic molecule that piques the interest of chemists due to its structural and functional intricacies. Here are some fascinating aspects:

  • Structural Complexity: This compound features a unique pentacyclic framework, which is notable for its potential to exhibit a variety of biological activities.
  • Functional Groups: The presence of multiple hydroxy groups suggests significant reactivity and the potential for hydrogen bonding, which can influence solubility and interaction with biological systems.
  • Vinylic Functionalities: The vinyl group in its structure can participate in various addition reactions, making it a potential building block for further synthetic transformations.
  • Diazacyclo Architecture: The 3,13-diazapenta structure contributes to the overall stability and unique properties of the molecule, potentially impacting its pharmacokinetic profiles in biological applications.

Moreover, chemists might describe this compound as a "tour de force" in synthetic organic chemistry, providing opportunities for research into:

  • Natural product synthesis
  • Pharmaceutical development
  • Material science due to its versatile chemical properties

Overall, the study of this compound enriches our understanding of complex organic molecules and opens pathways for innovative applications in various scientific disciplines.