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Mitomycin C

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Identification
Molecular formula
C15H18N4O5
CAS number
50-07-7
IUPAC name
1,8-bis(aziridin-1-yl)octane-1,8-dione
State
State

At room temperature, Mitomycin C is typically found as a solid. It should be handled with care and proper protective equipment due to its potential toxic effects. It is commonly used in solution for laboratory applications but is provided as a solid for storage stability.

Melting point (Celsius)
360.00
Melting point (Kelvin)
633.15
Boiling point (Celsius)
302.00
Boiling point (Kelvin)
575.15
General information
Molecular weight
334.32g/mol
Molar mass
334.3240g/mol
Density
1.3000g/cm3
Appearence

Mitomycin C typically appears as a blue or purple crystalline solid depending on purity. Upon exposure to air, it is likely to degrade or change slightly, affecting the color and form. It should be stored in a dark, cool place to extend its stability. When packaged for laboratory use, it often appears as a lyophilized powder or solid for reconstitution.

Comment on solubility

Solubility of 1,8-bis(aziridin-1-yl)octane-1,8-dione

1,8-bis(aziridin-1-yl)octane-1,8-dione exhibits distinct solubility characteristics that merit discussion. Understanding the factors influencing its solubility can help predict its behavior in various environments:

  • Polarity: The presence of the aziridine moieties can introduce aspects of polarity that affect solvation. Polar compounds tend to dissolve well in polar solvents.
  • Hydrophobic and Hydrophilic Balance: This compound features both hydrophobic octane chains and potentially hydrophilic dione groups, leading to varying solubility depending on the solvent.
  • Solvent Compatibility: A good rule of thumb is "like dissolves like." Therefore, it is likely to have enhanced solubility in organic solvents such as acetone, ethanol, or dimethyl sulfoxide (DMSO), while having reduced solubility in water.

It is important to note that solubility can also be influenced by factors such as temperature and pressure, making empirical testing often essential. In many cases, the temperature increase can enhance solubility due to increased molecular motion, while pressure changes may have minimal effects on liquid solubility but significant effects in gaseous solutes.

In summary, while the precise solubility of 1,8-bis(aziridin-1-yl)octane-1,8-dione may require experimental verification, its characteristics suggest a soluble nature in non-polar to moderately polar organic solvents, while demonstrating limitations in aqueous environments.

Interesting facts

Interesting Facts about 1,8-bis(aziridin-1-yl)octane-1,8-dione

1,8-bis(aziridin-1-yl)octane-1,8-dione is a fascinating compound that showcases the complexity and versatility of organic chemistry. Here are some intriguing points to consider:

  • Structural Uniqueness: This compound contains two aziridine rings, which are three-membered cyclic amines. The presence of these rings contributes to its chemical reactivity and physical properties, making it an interesting candidate for various reactions.
  • Biological Significance: Compounds with aziridine moieties have been studied for their potential in medicinal chemistry. They are known for their ability to act as electrophiles and potentially engage in interactions with biological macromolecules.
  • Versatile Applications: The presence of carbonyl groups in its structure provides potential for diverse applications, including:
    • As a precursor in the synthesis of pharmaceuticals.
    • In the development of polymers and materials.
    • As a reagent in organic synthesis.
  • Historical Context: The study of aziridines began in the mid-20th century, leading to a wide array of research exploring their utility in synthetic chemistry and medicinal applications.
  • Research Opportunities: The reactivity of compounds like 1,8-bis(aziridin-1-yl)octane-1,8-dione opens up new avenues for research, particularly in the development of novel reaction mechanisms and the creation of complex molecules.

In summary, 1,8-bis(aziridin-1-yl)octane-1,8-dione is not merely a compound but a testament to the intricate dance of atoms and bonds that define chemical science. Its potential in both laboratory and real-world applications continues to inspire chemists and researchers alike.

Synonyms
7425-91-4
AZIRIDINE, 1,1'-HEXAMETHYLENEDICARBONYLDI-
BRN 1315695
1,1'-Hexamethylenedicarbonyldiaziridine
AI3-50889
Aziridine, 1,1'-(1,8-dioxo-1,8-octanediyl)bis-
DTXSID80225254