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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione
State
State

Camptothecin is found in a solid state at room temperature. It is usually manipulated in its crystalline form for laboratory and research purposes. Being a solid, it typically requires dissolution in a suitable solvent for application.

Melting point (Celsius)
268.00
Melting point (Kelvin)
541.15
Boiling point (Celsius)
552.60
Boiling point (Kelvin)
825.75
General information
Molecular weight
348.35g/mol
Molar mass
348.3530g/mol
Density
1.4399g/cm3
Appearence

Camptothecin typically appears as a pale yellow crystalline solid. It is well-known for its limited solubility in water but is soluble in most organic solvents like DMSO, methanol, and ethanol. Its crystalline nature is often highlighted by its lustrous and transparent appearance, which is typical for many pure organic compounds.

Comment on solubility

Solubility Characteristics

The compound 19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione (C20H16N2O4) exhibits intriguing solubility properties. Understanding its solubility is essential for various applications, particularly in pharmaceuticals and organic synthesis.


Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups typically increases solubility in polar solvents, such as water.
  • Molecular Structure: Its complex tricyclic structure may contribute to a varied solubility profile, possibly limiting solubility in non-polar solvents.
  • Concentration: Higher concentrations of this compound in solution can lead to precipitation, especially in less polar environments.

In summary, due to its unique structural features and functional groups, this compound's solubility is likely to be dependent on the solvent type and the temperature of the solution. Further experimental data is essential to fully elucidate its solubility behaviors in various solvents.

Interesting facts

Interesting Facts about 19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione

This compound, while it may sound complex, offers intriguing insights into the intersection of organic chemistry and medicinal applications. Here are some notable aspects:

  • Unique Structure: The compound is characterized by a complex tricyclic framework, which is often found in various natural products and can lead to unique biological activities.
  • Potential Biological Activity: Compounds like this, with multiple hydroxyl (-OH) groups and a methylene bridge, can exhibit significant pharmacological properties. They may have influence in areas such as anticancer, antifungal, and anti-inflammatory research.
  • Role of Nitrogen: The presence of azatricyclo units indicates that nitrogen plays an integral role in the compound's structure, which may affect its reactivity and biological properties.
  • Synthesis Challenges: The synthetic pathway to create this molecule might involve multi-step reactions, showcasing the challenges chemists face in constructing complex organic frameworks. Synthesize these compounds often requires precision and innovation in methodology.
  • Inspiring Research: The structural complexity and potential applications in medicinal chemistry make this compound an exciting subject for research, inviting investigations into its synthesis, reactivity, and possible therapeutic effects.

As emphasized by the renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound exemplifies how intricate molecules can inspire innovative research avenues that potentially lead to groundbreaking discoveries.

In conclusion, while 19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione may seem daunting, its exploration can reveal much about the fascinating world of chemical compounds and their remarkable properties.

Synonyms
dihydrocytochalasin B
39156-67-7
(1S,6R,10R,12E,14S,15S,17S,18S,19S)-19-Benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione
CHEBI:201459
NS00057749