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2-Aminobenzimidazole

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Identification
Molecular formula
C7H7N3
CAS number
934-32-7
IUPAC name
1H-benzimidazol-2-amine
State
State

At room temperature, 2-Aminobenzimidazole is generally in a solid state, typically being an off-white to light brown crystalline powder.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
335.00
Boiling point (Kelvin)
608.15
General information
Molecular weight
133.16g/mol
Molar mass
133.1590g/mol
Density
1.2580g/cm3
Appearence

2-Aminobenzimidazole typically appears as an off-white to light brown crystalline powder. It is often used in its solid form in various chemical applications.

Comment on solubility

Solubility of 1H-benzimidazol-2-amine

1H-benzimidazol-2-amine, a compound known for its interesting structural characteristics, exhibits varying solubility profiles in different solvents. Here are some key points to note about its solubility:

  • Water Solubility: This compound has limited solubility in water due to its hydrophobic aromatic rings which impede interaction with polar water molecules.
  • Organic Solvents: However, 1H-benzimidazol-2-amine is more soluble in organic solvents, such as:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
    • Acetone
  • Temperature Effect: The solubility may increase with temperature, allowing for better dissolution in various solvents when heated.
  • pH Dependency: The solubility could also be affected by pH changes, especially in the presence of acids or bases that can protonate the amine group, potentially increasing solubility.

As a result, while 1H-benzimidazol-2-amine may not readily dissolve in water, its affinity for organic solvents makes it versatile in various chemical reactions and applications. In summary, the solubility characteristics of this compound underscore its behavior in different environments, which is crucial for its practical use in chemical processes.

Interesting facts

Interesting Facts about 1H-benzimidazol-2-amine

1H-benzimidazol-2-amine is a fascinating organic compound that belongs to the benzimidazole family. It is recognized for its remarkable structural features and diverse applications in various fields of science:

  • Pharmaceutical Applications: This compound has garnered attention in medicinal chemistry. It is often explored for its potential as a therapeutic agent, particularly in antimicrobial and anticancer treatments.
  • Biological Importance: The benzimidazole scaffold is essential in many biologically active molecules, often acting as a crucial component in the development of drugs. Its distinct structure allows for interaction with biological targets.
  • Synthetic Routes: The synthesis of 1H-benzimidazol-2-amine can be achieved through various methods, including the condensation reactions between o-phenylenediamine and carbonyl compounds. This versatility in synthesis opens pathways for the generation of derivatives.
  • Research Opportunities: Due to its interesting chemistry and biological properties, research on this compound is ongoing. Scientists continually investigate new synthetic pathways and modifications to enhance its efficacy and safety.
  • Structural Insights: The nitrogen atoms in the benzimidazole ring can participate in hydrogen bonding, which can influence the compound's solubility and interaction with other molecules, making it a subject of interest in structural bioinformatics.

In conclusion, 1H-benzimidazol-2-amine not only plays an important role in various scientific disciplines, but it also symbolizes the intersection of chemistry, biology, and technology. As researchers delve deeper into its properties and applications, there’s no doubt that this compound will continue to reveal even more intriguing aspects.

Synonyms
2-AMINOBENZIMIDAZOLE
934-32-7
1H-Benzimidazol-2-amine
2-Iminobenzimidazoline
2-Amino-1H-benzimidazole
Benzimidazol-2-ylamine
2-Benzimidazolamine
2-Amino benzimidazole
USAF EK-4037
Caswell No. 033AA
CCRIS 4354
NSC 7628
EINECS 213-280-6
2-aminobenzimidazol
NSC 27793
BRN 0116525
DTXSID1024465
CHEBI:27822
AI3-60094
E65DE7521V
NSC-7628
NSC-27793
AMINOBENZIMIDAZOLE, 2-
DTXCID004465
5-25-10-00372 (Beilstein Handbook Reference)
2-benzimidazolylamine
inchi=1/c7h7n3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4h,(h3,8,9,10
1H-Benzo[d]imidazol-2-amine
Benzimidazole, 2-amino-
1H-1,3-benzodiazol-2-amine
MFCD00005596
2-amino-benzimidazole
1H-benzimidazol-2-ylamine
1H-Benzoimidazol-2-ylamine
CHEMBL305513
162938-41-2
2H-Benzimidazol-2-imine,1,3-dihydro-(9CI)
WLN: T56 BM DNJ CZ
aminobenzimidazole
CAS-934-32-7
UNII-E65DE7521V
2fpz
benzimidazole amine
benzimidazole-amine
2-ammobenzimidazole
AX7
2-aminobenzoimidazole
Carbendazim metabolite
2fx6
1H-benzoimidazol-2-amine
Imidazole C-2 deriv. 3
SCHEMBL9098
2-Aminobenzimidazole, 97%
Oprea1_243328
YSWG454
JMC524454 Compound 5
MLS001074865
1H-benz[d]imidazole-2-amine
BIDD:GT0837
1H-1,3-benzimidazol-2-amine
BDBM7960
SCHEMBL2475507
SCHEMBL3350089
NSC7628
HMS1741L08
HMS2865C12
SRCA-00001
CS-D1373
HY-Y0410
NSC27793
STR00452
2-AB (2-Amine-1H-benzimidazole)
Tox21_201949
Tox21_303120
BBL033933
STL283126
AKOS000104081
FA00990
SB75578
NCGC00091178-01
NCGC00091178-02
NCGC00257027-01
NCGC00259498-01
AC-15858
SMR000019082
SY032901
TS-01718
1,3-dihydro-benzoimidazol-2-ylidene amine
DB-346953
A0850
EU-0067838
NS00010870
EN300-18977
W10172
AQ-738/40188880
2-Iminobenzimidazoline SRIRAMCHEM-aminobenzimidazole
Q27103356
2-Aminobenzimidazole, PESTANAL(R), analytical standard
F0266-1828
Z104378302