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2-(2-chlorophenyl)-1H-benzimidazol-1-ylmethanol

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Identification
Molecular formula
C14H11ClN2O
CAS number
89250-46-8
IUPAC name
1H-benzimidazol-2-yl-(2-chlorophenyl)methanol
State
State

The compound is a solid at room temperature. It is typically handled in its solid crystalline form.

Melting point (Celsius)
219.00
Melting point (Kelvin)
492.15
Boiling point (Celsius)
449.60
Boiling point (Kelvin)
722.75
General information
Molecular weight
242.70g/mol
Molar mass
242.6900g/mol
Density
1.3470g/cm3
Appearence

The compound appears as a crystalline solid, often fine and white or off-white in color. It is generally stable under normal conditions.

Comment on solubility

Solubility of 1H-benzimidazol-2-yl-(2-chlorophenyl)methanol

1H-benzimidazol-2-yl-(2-chlorophenyl)methanol, a compound with interesting structural features, exhibits specific solubility characteristics that are worth noting. Understanding its solubility can aid in its applications and utilization:

  • Polar Character: The presence of the benzimidazole and chlorophenyl groups generally suggests polarity, which often enhances solubility in polar solvents.
  • Solvent Interaction: This compound likely dissolves well in organic solvents such as methanol, ethanol, and DMSO due to potential hydrogen bonding and dipole-dipole interactions.
  • Limitations: However, it may have limited solubility in non-polar solvents like hexane or benzene, stemming from its polar functional groups.
  • Temperature Dependency: As with many compounds, solubility may increase with temperature, facilitating higher concentrations in solution.

In summary, while 1H-benzimidazol-2-yl-(2-chlorophenyl)methanol shows promising solubility in polar solvents, careful selection of the solvent and consideration of environmental conditions are essential for optimal dissolution and subsequent applications.

Interesting facts

Interesting Facts about 1H-benzimidazol-2-yl-(2-chlorophenyl)methanol

The compound 1H-benzimidazol-2-yl-(2-chlorophenyl)methanol is an intriguing member of the benzimidazole family, known for its diverse applications in various fields, particularly in medicinal chemistry. Here are some fascinating aspects of this compound:

  • Pharmacological Importance: Benzimidazole derivatives are widely recognized for their biological activity. Many compounds within this family exhibit promising antiparasitic, antimicrobial, and anticancer properties, making them valuable in drug development.
  • Mechanism of Action: The benzimidazole moiety often functions by interfering with the polymerization of tubulin, thereby disrupting cellular processes. This mechanism is crucial for the efficacy of some benzimidazole-based medications.
  • Versatile Synthesis: The synthesis of 1H-benzimidazol-2-yl-(2-chlorophenyl)methanol typically involves the condensation of appropriate amino acids and isocyanates, showcasing the versatility of synthetic pathways in organic chemistry.
  • Chlorophenyl Substituent: The presence of a 2-chlorophenyl group enhances the compound’s lipophilicity, potentially improving its bioavailability. Modifying substituents can significantly influence the pharmacokinetic properties of this class of compounds.
  • Research Potential: Scientists continue to explore the vast potential of benzimidazole derivatives, investigating new modifications that could lead to novel therapeutic agents. As research progresses, the compound’s unique characteristics may contribute to advancements in targeted therapy and personalized medicine.

In summary, 1H-benzimidazol-2-yl-(2-chlorophenyl)methanol exemplifies the significant impact that structurally complex compounds can have in the realm of pharmaceuticals. Its multifaceted properties and continued research ensure it remains an exciting subject of study for chemists and medicinal scientists alike.

Synonyms
alpha-(o-Chlorophenyl)-2-benzimidazolemethanol
5028-36-4
BRN 0664554
2-BENZIMIDAZOLEMETHANOL, alpha-(o-CHLOROPHENYL)-
DTXSID30964560
(1H-Benzimidazol-2-yl)(2-chlorophenyl)methanol