Skip to main content

1H-Benzimidazol-2-yl-(4-chlorophenyl)methanol

ADVERTISEMENT
Identification
Molecular formula
C14H11ClN2O
CAS number
31108-13-1
IUPAC name
1H-benzimidazol-2-yl-(4-chlorophenyl)methanol
State
State

At room temperature, 1H-Benzimidazol-2-yl-(4-chlorophenyl)methanol is typically a solid. It remains stable under standard conditions.

Melting point (Celsius)
243.00
Melting point (Kelvin)
516.15
Boiling point (Celsius)
545.30
Boiling point (Kelvin)
818.50
General information
Molecular weight
272.71g/mol
Molar mass
272.7140g/mol
Density
1.3600g/cm3
Appearence

Appearance: 1H-Benzimidazol-2-yl-(4-chlorophenyl)methanol is typically found as a crystalline solid. It is often characterized by its granular texture and off-white to tan color. The exact color and form of crystals may vary slightly depending on purity and specific conditions of crystallization.

Comment on solubility

Solubility of 1H-benzimidazol-2-yl-(4-chlorophenyl)methanol

The solubility of 1H-benzimidazol-2-yl-(4-chlorophenyl)methanol can be influenced by several factors, making it an intriguing compound to study.

Factors Affecting Solubility

  • Polarity: The presence of both the benzimidazole and chlorophenyl groups contributes to the compound's overall polarity.
  • Functional Groups: The hydroxyl (-OH) group in methanol significantly impacts solubility characteristics in polar solvents.
  • Solvent Choice: Solubility may be higher in polar solvents like water or methanol compared to non-polar solvents such as hexane.

As a general observation, compounds that contain polar functional groups tend to be soluble in polar solvents. Therefore, one might expect that:

  • 1H-benzimidazol-2-yl-(4-chlorophenyl)methanol has a tendency to dissolve well in water and alcohols.
  • In contrast, its solubility in non-polar organic solvents may be limited.

In summary, the solubility of this compound can be described as:

  • High solubility in polar solvents,
  • Low solubility in non-polar solvents.

Understanding the solubility characteristics is essential for applications ranging from pharmaceuticals to agricultural chemicals, as it influences the compound's utility and bioavailability.

Interesting facts

Interesting Facts about 1H-benzimidazol-2-yl-(4-chlorophenyl)methanol

1H-benzimidazol-2-yl-(4-chlorophenyl)methanol is a fascinating chemical compound that has attracted attention in various scientific fields. Here are some intriguing aspects of this compound:

  • Unique Structure: The compound features a benzimidazole ring, which is known for its planar structure and ability to participate in hydrogen bonding, making it a valuable scaffold in medicinal chemistry.
  • Functional Groups: The presence of both the 4-chlorophenyl and the hydroxymethyl groups contributes to its versatile reactivity and functionality, which may lead to interesting biological activities.
  • Biological Significance: Compounds containing benzimidazole moieties have been studied for their potential as antimicrobial agents, antitumor drugs, and anti-inflammatory medications, highlighting their importance in drug development.
  • Composition: The combination of a heterocyclic structure with a halogenated phenyl group opens pathways for exploring different interactions and enhancing biological activity.
  • Research Potential: Scientists are continuously investigating the pharmacological properties of benzimidazole derivatives. They may provide insight into new therapeutic approaches for treating various diseases.

This compound is a prime example of how structural modifications can lead to enhanced efficacy and selectivity in drug design. As researchers delve deeper into its properties, we may uncover valuable information that could revolutionize treatments in the medical field.

Synonyms
5028-38-6
NSC 202591
BRN 0751207
alpha-(p-Chlorophenyl)-2-benzimidazolemethanol
5-23-12-00353 (Beilstein Handbook Reference)
alpha-(4-Chlorophenyl)-1H-benzimidazole-2-methanol
2-BENZIMIDAZOLEMETHANOL, alpha-(p-CHLOROPHENYL)-
2-(p-chloro-alpha-hydroxybenzyl)benzimidazole
(1H-Benzo[d]imidazol-2-yl)(4-chlorophenyl)methanol
HBBPC (free base)
1H-benzimidazol-2-yl-(4-chlorophenyl)methanol
(1H-1,3-benzodiazol-2-yl)(4-chlorophenyl)methanol
NSC202591
NSC-202591