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4-Amino-1H-benzimidazole

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Identification
Molecular formula
C7H7N3
CAS number
3615-56-3
IUPAC name
1H-benzimidazol-4-amine
State
State
4-Amino-1H-benzimidazole is typically a solid at room temperature. It is usually encountered as a crystalline powder, maintaining its stability under standard environmental conditions.
Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
365.15
Boiling point (Kelvin)
638.30
General information
Molecular weight
133.15g/mol
Molar mass
133.1500g/mol
Density
1.3104g/cm3
Appearence

4-Amino-1H-benzimidazole typically appears as a white to off-white crystalline powder. It is a solid compound and may exhibit some degree of hygroscopicity, depending on environmental conditions.

Comment on solubility

Solubility of 1H-benzimidazol-4-amine

The solubility of 1H-benzimidazol-4-amine is a significant aspect to consider when evaluating its applications in various chemical processes. This compound generally displays moderate solubility in organic solvents, with particular tendencies noted:

  • Water Solubility: 1H-benzimidazol-4-amine is relatively sparingly soluble in water, which may limit its use in aqueous environments.
  • Solubility in Organic Solvents: It shows enhanced solubility in organic solvents such as methanol and ethanol, making these solvents preferable for reactions or formulations involving this compound.
  • Temperature Dependent: As with many compounds, the solubility increases with temperature; thus, higher temperatures can aid in dissolving this compound more efficiently.

Understanding the solubility characteristics of 1H-benzimidazol-4-amine can facilitate its effective utilization in synthesis and development processes. As the saying goes, "like dissolves like," and therefore, the choice of solvent is critical when working with this compound. Always consider the nature of the surrounding medium to achieve optimal solubility outcomes.

Interesting facts

Exploring 1H-benzimidazol-4-amine

1H-benzimidazol-4-amine, often simply referred to as benzimidazole, is a fascinating compound that belongs to a class of organic compounds known for their diverse biological activities. Here are some intriguing aspects of this unique molecule:

  • Pharmaceutical Applications: 1H-benzimidazol-4-amine serves as a crucial building block in the synthesis of various pharmaceutical agents. It has been studied for its potential to act against cancer and parasitic infections.
  • Biological Activity: The compound exhibits several notable biological properties, such as:
    • Antimicrobial effects that can combat certain bacterial strains.
    • Anti-inflammatory benefits, making it a candidate for treatments involving inflammatory diseases.
    • Potential roles in the inhibition of enzymes linked to various diseases.
  • Structural Features: The structure of 1H-benzimidazol-4-amine consists of a fused benzene and imidazole ring, contributing to its chemical stability and interaction with biological targets. The presence of the amino group enhances its reactivity and functionality.
  • Research Potential: As a versatile compound, 1H-benzimidazol-4-amine has attracted significant attention in materials science, organic synthesis, and medicinal chemistry. Ongoing research is exploring its role in developing new therapeutic agents.
  • Environmental Concerns: The environmental fate of similar benzimidazole derivatives is an area of active study, particularly considering their potential impact on ecosystems when used in agricultural applications.

In summary, 1H-benzimidazol-4-amine is not just a simple organic compound; it is a significant player in the realm of medicinal chemistry and biological research. As scientists continue to explore its properties and applications, this compound may unlock new paths towards innovative therapies and solutions to pressing health challenges.

Synonyms
4331-29-7
1H-Benzimidazol-4-amine
1H-benzimidazol-7-amine
4-Aminobenzimidazole
1H-1,3-benzodiazol-4-amine
BENZIMIDAZOLE, 4-AMINO-
7-Aminobenzimidazole
1H-Benzimidazole-4-amine
1H-benzimidazol-4-ylamine
Benzimidazole, 4(or 7)-amino-
4I33QGV1TN
NSC 143985
NSC-143985
BENZIMIDAZOL-4-YLAMINE
DTXSID20195821
DTXCID60118312
1H-Benzimidazol-4-amine (9CI)
Benzimidazole, 4(or 7)-amino-(7CI)
800-877-7
1H-BENZO[D]IMIDAZOL-7-AMINE
1H-benzo[d]imidazol-4-amine
3H-BENZO[D]IMIDAZOL-4-AMINE
1H-Benzimidazol-7-amine(9CI)
69984-77-6
MFCD01658254
4-Amino-1H-benzimidazole
7WA
NSC143985
UNII-4I33QGV1TN
1H-benzoimidazol-4-ylamine
1H-benzoimidazol-4-yl-amine
SCHEMBL312427
4-AMINOBENZIMIDAZOLE HCL
NZJKEQFPRPAEPO-UHFFFAOYSA-N
BCP32844
STK505486
AKOS005171772
AKOS015890340
CS-W006218
SB22907
NCGC00184184-01
BS-13308
SY025999
EU-0020139
EN300-58070
B67426
P10197
1H-benzo[d]imidazol-4-amine;4-Aminobenzimidazole
AT-051/40231700
Z1259162108