2-Mercaptobenzimidazole | Solubility of Things

Identification

Molecular formula

C₇H₆N₂S

CAS number

583-39-1

IUPAC name

1H-benzimidazole-2-thiol

State

At room temperature, 2-Mercaptobenzimidazole exists as a solid.

Melting point (Celsius)

302.00

Melting point (Kelvin)

575.15

Boiling point (Celsius)

406.00

Boiling point (Kelvin)

679.15

General information

Molecular weight

150.21g/mol

Molar mass

150.2070g/mol

Density

1.4000g/cm³

Appearence

2-Mercaptobenzimidazole typically appears as light cream to pale yellow crystals or crystalline powder. It usually exhibits slight sulfurous odor.

Comment on solubility

Solubility of 1H-benzimidazole-2-thiol

1H-benzimidazole-2-thiol, with the chemical formula C₇H₆N₂S, exhibits interesting solubility properties that are influenced by its molecular structure. Below are some key points regarding its solubility:

Polar Character: The presence of the thiol (-SH) group contributes to its polar nature, which can enhance solubility in polar solvents.
Solvent Compatibility: 1H-benzimidazole-2-thiol is known to be soluble in alcohols and dimethyl sulfoxide (DMSO), but it has limited solubility in non-polar solvents like hexane.
Water Solubility: Its overall solubility in water is moderate, suggesting some potential for interaction with water molecules, although it is not significantly soluble.
pH Dependency: The solubility can also be affected by the pH of the solution, as the thiol group can easily protonate or deprotonate under different pH conditions.

In conclusion, while ^1H-benzimidazole-2-thiol can be expected to have a moderate solubility in certain polar solvents, its solubility behavior can vary significantly depending on the solvent environment and solution conditions. Understanding these nuances is crucial for applications in chemical synthesis and pharmaceutical formulations.

Interesting facts

Interesting Facts About 1H-benzimidazole-2-thiol

1H-benzimidazole-2-thiol, often referred to simply as benzimidazole thiol, is a fascinating compound with a range of applications, particularly in the field of medicinal chemistry and material science. Here are some intriguing facts about this compound:

Biological Activity: 1H-benzimidazole-2-thiol has been shown to exhibit significant biological activity, particularly in its role as a potential therapeutic agent. It has been investigated for its antibacterial, antifungal, and antiviral properties, showcasing the versatility of its structure in different biological contexts.
Antioxidant Properties: This compound has been recognized for its antioxidant capabilities, suggesting it may play a role in combating oxidative stress in cells, an important factor in aging and various diseases.
Structural Significance: The benzimidazole core is a well-known motif in numerous pharmaceuticals. The presence of a thiol group (–SH) enhances its potential reactivity, facilitating interactions with biological macromolecules and making it a valuable scaffold for drug development.
Research Applications: Scientists are exploring 1H-benzimidazole-2-thiol for its applications in the synthesis of nanoparticles and as a ligand in coordination chemistry, highlighting its potential in advancing materials science.
Pharmaceutical Relevance: Due to its diverse biological activities, benzimidazole derivatives are often investigated for use in treatments for conditions such as cancer, bacterial infections, and even parasitic diseases.

In conclusion, 1H-benzimidazole-2-thiol stands out not only for its compelling biological profile but also for its broad applicability in various scientific realms. Its promising properties make it a compound of great interest for continued research, with the potential to contribute to advancements in pharmacology and materials technology. As Albert Szent-Györgyi once said, "Discovery consists of seeing what everybody has seen and thinking what nobody has thought." This captures the essence of why compounds like 1H-benzimidazole-2-thiol hold such promise in scientific exploration.