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Imidazole-2-carboxaldehyde

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Identification
Molecular formula
C4H4N2O
CAS number
3034-50-2
IUPAC name
1H-imidazole-2-carbaldehyde
State
State

At room temperature, imidazole-2-carboxaldehyde is in a crystalline solid state.

Melting point (Celsius)
88.00
Melting point (Kelvin)
361.15
Boiling point (Celsius)
131.00
Boiling point (Kelvin)
404.15
General information
Molecular weight
96.09g/mol
Molar mass
96.0900g/mol
Density
1.1510g/cm3
Appearence

Imidazole-2-carboxaldehyde appears as a white to off-white crystalline solid. It is typically presented in the form of small crystals or a crystalline powder.

Comment on solubility

Solubility of 1H-Imidazole-2-carbaldehyde

1H-Imidazole-2-carbaldehyde, with its unique structure, yields interesting solubility characteristics:

  • Polar Nature: This compound exhibits a polar nature due to the presence of both nitrogen atoms in the imidazole ring and the aldehyde functional group. As a result, it is expected to dissolve readily in polar solvents.
  • Solvent Compatibility: Common solvents that can dissolve 1H-imidazole-2-carbaldehyde effectively include:
    • Water
    • Methanol
    • Ethanol
    • Dimethyl sulfoxide (DMSO)
  • Limited Solubility in Non-polar Solvents: Conversely, the compound shows low solubility in non-polar solvents such as hexane or benzene due to the lack of favorable interactions.

This differential solubility is a common characteristic of many nitrogen-containing compounds, influencing their application in various chemical contexts. The ability to dissolve well in polar solvents while being limited in non-polar ones highlights the importance of solvent selection when working with 1H-imidazole-2-carbaldehyde.

Interesting facts

Interesting Facts About 1H-Imidazole-2-carbaldehyde

1H-Imidazole-2-carbaldehyde is a versatile compound that boasts a variety of applications in both the scientific and industrial fields. Here are some intriguing aspects to consider:

  • Biological Relevance: This compound is noteworthy due to its role as a building block in the synthesis of numerous biologically active molecules. Its imidazole ring is a common structural feature found in many important biomolecules, including histidine, an essential amino acid.
  • Medicinal Chemistry: 1H-Imidazole-2-carbaldehyde serves as an important precursor in the development of pharmaceuticals. It has been studied for its potential anti-inflammatory and antimicrobial properties, making it a focal point for drug discovery.
  • Versatile Synthetic Intermediate: This compound is often used in organic synthesis, aiding in the creation of various heterocyclic compounds and complex molecular architectures. Its unique chemical structure allows for diverse reaction pathways.
  • Chemical Reactivity: The presence of the aldehyde functional group makes 1H-imidazole-2-carbaldehyde a potent reactant in various chemical transformations, including condensation reactions, which can be harnessed to yield compounds with desired properties.
  • Research Potential: Given its unique properties, ongoing research is uncovering more about the compound’s reactivity and interactions, which can lead to new applications and enhanced materials.

As scientists continue exploring the potential of 1H-imidazole-2-carbaldehyde, it is evident that this compound holds significant importance in various fields including biochemistry, medicinal chemistry, and materials science. Its unique structure and reactivity make it a fascinating subject for further investigation.

Synonyms
1H-Imidazole-2-carbaldehyde
Imidazole-2-carboxaldehyde
600-165-4
10111-08-7
2-Formylimidazole
1H-IMIDAZOLE-2-CARBOXALDEHYDE
2-Imidazolecarboxaldehyde
imidazole-2-aldehyde
Imidazole-2-carbaldehyde
MFCD00003544
1H-Imidazolecarboxaldehyde
2-Formyl-1H-imidazole
formylimidazole
imidazolealdehyde
2-formyl imidazole
2-formyl-imidazole
Imidazole-2-carboxaldehyde; 1H-Imidazole-2-carbaldehyde; 2-Formylimidazole; 2-Imidazolecarbaldehyde; 2-Imidazolylformaldehyde;
imidazole carbaldehyde
imidazolecarboxaldehyde
2-imidazolecarbaldehyde
2-imidazol-carbaldehyde
imidazol-2-carbaldehyde
2-imidazolcarboxaldehyde
imidazole-2-carboxaldeyde
2-imidazole carboxaldehyde
2-imidazole-carboxaldehyde
imidazole 2-carboxaldehyde
1H-2-imidazolecarbaldehyde
1H-imidazol-2-carbaldehyd
SCHEMBL7021
2-Formyl imidazole (Imidazole-2-carboxaldehyde)
1H-imidazole-2 carbaldehyde
SCHEMBL60147
1H-imidazole-2-carboaldehyde
YSWG441
1-H-imidazole-2-carbaldehyde
SCHEMBL1068625
SCHEMBL4928518
SCHEMBL5949359
SCHEMBL6696739
1H-Imidazole-2-carbaldehyde #
2-Imidazolecarboxaldehyde, 97%
SCHEMBL27399883
DTXSID70143736
BCP27080
STR04050
BBL104408
SBB004383
STK503765
AKOS004910734
AC-6503
CS-W007321
FI09933
HY-W007321
PB47438
PS-9350
BP-12787
ST056377
SY014217
DB-005097
I0809
NS00023025
EN300-52542
F8880-2426