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Imidazole-5-carboxylic acid

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Identification
Molecular formula
C4H4N2O2
CAS number
499-75-2
IUPAC name
1H-imidazole-5-carboxylic acid
State
State

At room temperature, Imidazole-5-carboxylic acid is typically found in a solid state. It is commonly encountered as a fine powder or crystalline form.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.00
Boiling point (Celsius)
404.00
Boiling point (Kelvin)
677.00
General information
Molecular weight
112.09g/mol
Molar mass
112.0860g/mol
Density
1.6604g/cm3
Appearence

Imidazole-5-carboxylic acid is a white to off-white solid that is often available in powder or crystalline form. It may be slightly hygroscopic, meaning it can absorb moisture from the air. Its appearance might vary slightly with formulation and purity.

Comment on solubility

Solubility of 1H-imidazole-5-carboxylic acid

1H-imidazole-5-carboxylic acid, often referred to as imidazole-5-carboxylic acid, exhibits interesting solubility characteristics that are influenced by its molecular structure.

Solubility Profile

This compound tends to be:

  • Soluble in water: Its polar functional groups allow it to interact with water molecules effectively, leading to a significant degree of solubility.
  • Soluble in organic solvents: Solvents such as methanol and ethanol can also dissolve this compound due to similar polar characteristics.
  • Limited solubility in non-polar solvents: Compounds like hexane or chloroform are less effective in dissolving imidazole-5-carboxylic acid due to a lack of polar interaction.

Factors Affecting Solubility

The solubility of 1H-imidazole-5-carboxylic acid can be affected by several factors, including:

  • Temperature: Higher temperatures can enhance solubility in solvents.
  • pH levels: The ionization of the carboxylic acid group can be influenced by the pH of the solution, impacting overall solubility.
  • Presence of salts: The "common ion effect" can also alter solubility through ionic interactions.

In summary, while 1H-imidazole-5-carboxylic acid shows excellent solubility in polar solvents, its solubility behavior can vary according to environmental conditions, making it an intriguing subject for further study in chemical research.

Interesting facts

Interesting Facts about 1H-Imidazole-5-Carboxylic Acid

1H-imidazole-5-carboxylic acid, commonly known for its role in various biological systems, is an intriguing compound that features a five-membered aromatic ring containing nitrogen. Here are some remarkable insights about this compound:

  • Biological Significance: This compound acts as a precursor to several important biomolecules, particularly in the synthesis of histidine, an essential amino acid involved in protein synthesis and enzymatic functions.
  • Pharmaceutical Applications: 1H-imidazole-5-carboxylic acid derivatives have been explored for their potential use in drug formulations due to their ability to interact with biological targets.
  • Catalytic Properties: Imidazole-containing compounds are often utilized as catalysts in various organic reactions, exploiting their unique ability to stabilize transition states.
  • Research and Development: The study of this compound falls within the realm of medicinal chemistry, where its derivatives are investigated for properties such as anti-inflammatory and antimicrobial activities.

In conclusion, 1H-imidazole-5-carboxylic acid is not just a chemical entity; it serves as a bridge between simple chemical structures and complex biological functions. As scientists continue to explore its potential, we may uncover new applications that can enhance our understanding of biology and chemistry alike.

As the well-known chemist Linus Pauling once said, "The best way to have a good idea is to have a lot of ideas." This perfectly encapsulates the spirit of researching compounds like 1H-imidazole-5-carboxylic acid.

Synonyms
1H-Imidazole-4-carboxylic acid
1072-84-0
1H-Imidazole-5-carboxylic acid
4-Imidazolecarboxylic acid
IMIDAZOLE-4-CARBOXYLIC ACID
4-Carboxyimidazole
EINECS 214-017-8
AE82Z8U4GJ
NSC 32340
IMCOOH
NSC-32340
DTXSID00147949
IMIDAZOLE-4(OR 5)-CARBOXYLIC ACID
J110.448I
imidazole-4-carboxylic acids
DTXCID5070440
CHEBI:38306
214-017-8
3H-Imidazole-4-carboxylic acid
imidazole-5-carboxylic acid
MFCD00082203
4-imidazole carboxylic acid
5-Imidazolic acid
UNII-AE82Z8U4GJ
imidazole, 4-carboxy-
4-Imidazolecarboxylic-acid
imidazol-4-carboxylic acid
4-imidazole-carboxylic acid
SCHEMBL70915
4(5)-imidazolecarboxylic acid
CHEMBL1773943
1H-Imidazol-3-ium-4-carboxylate
4-Imidazolecarboxylic acid, 98%
CHEBI:218399
1H-Imidazole-5-carboxylic acid #
(1H-imidazol-4-yl)carboxylic acid
ALBB-025706
BCP05792
NSC32340
STK392208
VT1381
AKOS001606632
AKOS008105105
AB03082
AC-6502
CS-W007695
FI11530
HY-W007695
PB47477
PS-5456
NCGC00341756-01
SY001178
TS-01557
3H-imidazole-4-carboxylic acid, AldrichCPR
DB-002073
I0607
NS00015752
EN300-62808
H57379
I67419
AB00173762-03
Q27273893
F1791-0473
Z993967082