Skip to main content

Indazol-3-amine

ADVERTISEMENT
Identification
Molecular formula
C7H7N3
CAS number
35498-01-8
IUPAC name
1H-indazol-3-amine
State
State

Indazol-3-amine is typically found in solid state under standard conditions of temperature and pressure (25 °C and 1 atm).

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
357.00
Boiling point (Kelvin)
630.15
General information
Molecular weight
133.15g/mol
Molar mass
133.1490g/mol
Density
1.3400g/cm3
Appearence

Indazol-3-amine typically appears as a crystalline solid. It can be either white or off-white in color, and is often found in powdered form.

Comment on solubility

Solubility of 1H-indazol-3-amine

1H-indazol-3-amine, with its intriguing structure, exhibits interesting solubility characteristics that can be crucial for various applications. Understanding the solubility of this compound is essential, particularly in pharmaceutical and biochemical contexts. Here are some key points regarding its solubility:

  • Water Solubility: The solubility of 1H-indazol-3-amine in water is generally considered low. This is attributed to its hydrophobic indazole structure, which often results in limited interaction with polar solvents.
  • Solubility in Organic Solvents: Conversely, 1H-indazol-3-amine is more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO). This property may be advantageous for applications requiring organic medium solubility.
  • Effect of pH: The solubility may also be influenced by pH levels. For instance, in more acidic or basic environments, its solubility can vary due to protonation or deprotonation of the amino group.
  • Temperature Influence: Like many organic compounds, the solubility of 1H-indazol-3-amine is expected to increase with temperature. This can be a vital consideration in synthesis processes or laboratory experiments.

In summary, the solubility of 1H-indazol-3-amine is characterized by:

  1. Low water solubility
  2. Higher solubility in organic solvents
  3. Influence of pH and temperature

These aspects play a significant role in how this compound can be utilized in different fields, emphasizing the importance of understanding solubility in chemical science.

Interesting facts

Interesting Facts about 1H-indazol-3-amine

1H-indazol-3-amine is a fascinating compound that has garnered the interest of researchers in various fields due to its unique structure and biological properties. Here are some intriguing aspects of this compound:

  • Structure and Chemistry: The compound features an indazole ring, a five-membered aromatic ring known for its aromaticity and stability, making it a valuable scaffold in medicinal chemistry.
  • Biological Activity: 1H-indazol-3-amine has been studied for its potential pharmacological effects, often showing activity against multiple targets, including kinases. This makes it a candidate for further drug development.
  • Synthetic Approaches: The synthesis of this compound can involve various methods, highlighting the creativity of synthetic chemists. Techniques often include cyclization reactions that can lead to modifications in the indazole framework.
  • Applications: Research indicates that derivatives of 1H-indazol-3-amine could be useful in treating conditions such as cancer and inflammation, making it an important part of ongoing research.
  • Research Significance: As scientists continually explore the properties of 1H-indazol-3-amine, it remains a subject of interest for understanding complex biological mechanisms and developing novel therapeutic compounds.

In summary, 1H-indazol-3-amine is not just another compound; it represents the intersection of organic chemistry and pharmacology, showcasing the potential of small molecules in the advancement of medical science. As research progresses, we may uncover even more thrilling possibilities associated with this chemical entity.

Synonyms
1H-Indazol-3-amine
874-05-5
3-AMINOINDAZOLE
3-Indazolamine
1H-Indazole, 3-amino-
NSC 44677
DTXSID5061243
1h-indazole-3-amine
DTXCID2048583
692-411-2
ydtdkkulpwthrv-uhfffaoysa-n
3-Amino-1H-indazole
1H-indazol-3-ylamine
2H-Indazol-3-amine
54107-84-5
1H-indazole-3-ylamine
INDAZOL-3-AMINE
NSC44677
MFCD00182045
CHEMBL1331627
NSC-44677
1H-Indazol-3-amine, monohydrochloride
aminoindazole
Amino-indazole
indazole amine
3nus
JNZ
3-amino benzpyrazole
1H-?Indazol-?3-?amine
NCIStruc1_001630
NCIStruc2_000161
Oprea1_470192
SCHEMBL18878
MLS001001985
SCHEMBL5299723
SCHEMBL14041182
1H-Indazol-3-amine, AldrichCPR
CHEBI:104899
1,2-dihydro-3H-indazol-3-imine
BDBM604504
HMS2604G05
ALBB-028239
BCP27432
NCI44677
AR2288
BBL104359
BDBM50339013
CCG-37665
NCGC00013536
NSC348887
STL414950
US11661426, Compound 353a
AKOS000115531
AKOS006222497
CCG-302505
CS-W002482
MB69235
NSC-348887
SB39259
NCGC00013536-02
NCGC00096649-01
BP-10432
DA-26181
NCI60_004031
SMR000353333
SY007051
DB-005098
DB-351708
EN300-02352
NSC 348887; NSC 44677
10.14272/YDTDKKULPWTHRV-UHFFFAOYSA-N.1
10P-212
AE-413/25046004
doi:10.14272/YDTDKKULPWTHRV-UHFFFAOYSA-N.1
Q27182567
Z56820416
1H-Indazol-3-ylamine; 3-Amino-1H-indazole; 3-Aminoindazole; 3-Indazolamine;