Skip to main content

1H-Indazole

ADVERTISEMENT
Identification
Molecular formula
C7H6N2
CAS number
271-44-3
IUPAC name
1H-indazole
State
State

At room temperature, 1H-Indazole is typically a solid. Its crystalline nature makes it stable in its solid state under standard laboratory conditions.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.15
Boiling point (Celsius)
321.00
Boiling point (Kelvin)
594.15
General information
Molecular weight
118.14g/mol
Molar mass
118.1390g/mol
Density
1.2050g/cm3
Appearence

1H-Indazole typically appears as a colorless to light yellow crystalline solid. It has a distinct aromatic odor, and its crystalline form showcases flat, plate-like habits. When pure, it is devoid of any color, but impurities can impart a yellowish tint.

Comment on solubility

Solubility of 1H-indazole

1H-indazole, a heterocyclic compound, exhibits interesting solubility properties that are worth exploring. Overall, its solubility can be affected by various factors, such as temperature, pH, and the presence of other solutes in solution.

Key Characteristics

  • General Solubility: 1H-indazole is known to be moderately soluble in organic solvents.
  • Water Solubility: It has limited solubility in water, making it less favorable for aqueous reactions.
  • Solvents: It tends to dissolve well in solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO).

In practical applications, this solubility profile can lead to variations in usage depending on the medium required for specific reactions. As quoted in the scientific literature, "The solubility of a compound is a pivotal aspect for its reactivity and application." Thus, understanding the solubility of 1H-indazole is crucial for researchers and industrial chemists alike.

In conclusion, the solubility behavior of 1H-indazole highlights its compatibility with non-polar and polar organic solvents, while its limited aqueous solubility suggests careful consideration when designing experiments or formulations involving this compound.

Interesting facts

Interesting Facts about 1H-Indazole

1H-Indazole is a fascinating heterocyclic compound that consists of a fused structure containing both an indole and a pyrazole ring. This unique configuration contributes to its varied chemical reactivity and biological significance.

Key Characteristics

  • Biological Relevance: 1H-Indazole has garnered attention in medicinal chemistry for its potential use in therapeutic applications. It exhibits promising anti-cancer, anti-inflammatory, and anti-bacterial properties.
  • Pharmaceutical Applications: The compound serves as a scaffold for the development of a variety of drug candidates, enhancing the search for new treatments.
  • Research Interests: Chemists and biochemists are continually exploring the synthesis and functionalization of 1H-Indazole to optimize its pharmacological profiles.

Notable Quotes

As noted by many researchers in the field, "The indazole framework opens doors to a multitude of chemical modifications, making it an exciting target for drug discovery." This highlights the compound's versatility and importance in the development of new therapeutics.

Applications in Chemistry

In addition to its medicinal importance, 1H-Indazole is significantly used in material science and organic synthesis due to its interesting electronic and optical properties. Researchers often utilize it as a building block for complex organic molecules.

Furthermore, the ability to modify the indazole structure allows chemists to tailor properties for specific applications, making it a compound of choice in various fields of research.

In summary, 1H-Indazole is not just a compound of theoretical interest; its practical applications in pharmaceuticals and material science underscore its importance in modern chemistry.

Synonyms
1H-Indazole
INDAZOLE
271-44-3
2H-indazole
Isoindazole
1H-Benzopyrazole
2-Azaindole
1,2-Diazaindene
271-42-1
Benzopyrazole
1,2-Benzodiazole
1H-indazol
1,2-Diazaindene (VAN)
EINECS 205-978-4
MFCD00005691
NSC 26336
1,2-Benzopyrazole
7C4VQE5C03
CHEBI:36669
NSC-26336
1H-INDAZOLE [MI]
DTXSID4075374
WLN: T56 BMNJ
Azaindole
Indazoles
indazol
UNII-7C4VQE5C03
1HBenzopyrazole
2Azaindole
2-Azoindole
1,2Diazaindene
2vta
1-H-indazole
Indazole, 5
Indazole, 6
LZ1
NSC90357
Indazole, 98%
4b2i
SCHEMBL6295
CHEMBL86795
SCHEMBL3056528
SCHEMBL5376344
SCHEMBL5376627
SCHEMBL5376678
SCHEMBL5379372
SCHEMBL5383265
DTXCID4037615
SCHEMBL17515466
BDBM24627
CHEBI:36670
CHEBI:36671
AAA27142
BCP27336
NSC26336
1,2-Benzodiazole;1,2-Benzopyrazole
MFCD20483705
NSC-90357
STL371246
AKOS000271187
AKOS024124233
CS-W008689
PB23156
PS-4750
HY-40294
SY001125
DB-024400
DB-182223
DB-329997
DB-351709
CS-0166940
I0278
NS00010847
EN300-44212
D83794
P10014
AB00376876-02
AC-907/25014165
Q417106
F0918-7060
F1918-0009
Z276614452
205-978-4