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5-Hydroxyindole

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Identification
Molecular formula
C8H7NO
CAS number
1133-45-3
IUPAC name
1H-indol-5-ol
State
State

At room temperature, 5-Hydroxyindole is typically in a solid state. It is in the form of a crystalline powder that can exist as fine particles or small crystals.

Melting point (Celsius)
191.00
Melting point (Kelvin)
464.15
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.15
General information
Molecular weight
133.15g/mol
Molar mass
133.1470g/mol
Density
1.4500g/cm3
Appearence

5-Hydroxyindole is a solid compound that appears as an off-white to light yellow crystalline powder. It may darken upon exposure to air or light, which is typical for compounds containing hydroxyl groups attached to aromatic rings.

Comment on solubility

Solubility of 1H-indol-5-ol

1H-indol-5-ol, also known as indole-5-ol, demonstrates interesting solubility properties that can be influenced by various factors. Here are some key points to consider:

  • Solvent Compatibility: 1H-indol-5-ol is generally soluble in organic solvents, such as ethanol and dichloromethane. This is due to its polar functional groups.
  • Hydrophilicity: The presence of a hydroxyl group (-OH) contributes to its increased polarity, enhancing *hydrophilicity*. Therefore, it can partially dissolve in water under certain conditions.
  • Temperature Effect: The solubility of 1H-indol-5-ol may also increase with temperature, which is typical for many organic compounds. Higher temperatures often help disrupt molecular interactions.

As a guideline, one might find that:

  1. In lower concentrations, 1H-indol-5-ol can exhibit *modest solubility* in water.
  2. In higher concentrations, it's best to use organic solvents for effective dissolution.

In summary, while 1H-indol-5-ol shows certain degrees of solubility in both polar and nonpolar environments, the choice of solvent and experimental conditions is crucial for achieving optimal results.

Interesting facts

Exploring the Fascinating World of 1H-indol-5-ol

1H-indol-5-ol, a compound originating from the indole family, is notable for its intriguing chemical structure and biological properties. As a scientist or student of chemistry, you'll find that this compound opens the door to both theoretical and practical applications in a variety of fields. Here are some interesting aspects to consider:

  • Biological Significance: 1H-indol-5-ol plays a role in various biological systems. It is often studied for its potential pharmacological activities, including its effects on the central nervous system.
  • Diverse Applications: This compound has implications in medicinal chemistry, especially in drug development. Its structure allows for the synthesis of derivatives that could be useful in treating diseases, including cancer.
  • Research Potential: The study of 1H-indol-5-ol is a growing field of interest. Scientists explore its reactivity and interaction with other chemical entities which may often lead to discoveries of novel compounds.
  • Environmental Impact: Like many indole derivatives, 1H-indol-5-ol is also relevant in studies of environmental chemistry, specifically in the synthesis of natural products and their degradation pathways.
  • Structural Versatility: The indole structure is known for its ability to participate in various chemical reactions, enabling the creation of a myriad of derivatives with different functionalities.

In conclusion, 1H-indol-5-ol is much more than just a simple organic compound. Its significance extends into various realms of research and application, marking it as a noteworthy subject for ongoing studies and innovations. As American chemist Robert H. Grubbs aptly stated, "The best way to predict the future is to invent it." By exploring compounds like 1H-indol-5-ol, we are indeed paving the path for new scientific advancements.

Synonyms
5-Hydroxyindole
1H-Indol-5-ol
1953-54-4
INDOL-5-OL
5-Hydroxy-1H-indole
Hydroxy-5 indole
Hydroxy-5 indole [French]
CCRIS 4422
UNII-320UN7XZYN
EINECS 217-782-6
320UN7XZYN
NSC 87503
NSC-87503
BRN 0112349
CHEBI:89649
DTXSID00173187
5-21-03-00018 (Beilstein Handbook Reference)
1 H-indol-5-ol
1H-Indol-5-ol (9CI)
DTXCID5095678
217-782-6
lmiqerwzrifwnz-uhfffaoysa-n
5-hydroxyindol
C8H7NO
MFCD00005677
5-Indolol
5-hydroxy-indole
Hydroxy-5 indole [French]
1H-Indol-5-ol; Indol-5-ol; 5-Hydroxy-1H-indole; NSC 87503;
5-hydroxylindole
5-hydroxy-indol
5-hydroxy indole
3fuh
5H1
1h-indole-5-ol
5Hydroxy-1H-indole
1-H-indol-5-ol
4b3c
5-Hydroxyindole, 97%
NCIOpen2_001272
WLN: T56 BMJ GQ
SCHEMBL50566
cid_16054
MLS000039632
5-HI
CHEMBL404923
GTPL2295
BDBM32212
HMS2188A10
KUC106613N
BCP27601
KSC-09-215B
NSC87503
BBL036782
STK580144
AKOS005206937
AB00494
AC-5464
CS-W001160
FH05516
HY-W001160
PS-3277
PD050590
SMR000037055
SY008069
DB-007056
H0252
NS00014753
EN300-79057
Q27073984
F0001-3470
Z1203162319