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Indolin-2,3-dione

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Identification
Molecular formula
C8H5NO2
CAS number
91-56-5
IUPAC name
1H-indole-2,3-diol
State
State

At room temperature, 1H-indole-2,3-diol is typically a solid. It is stable under standard conditions of temperature and pressure but should be stored in a cool, dry place to prevent degradation.

Melting point (Celsius)
203.00
Melting point (Kelvin)
476.00
Boiling point (Celsius)
261.00
Boiling point (Kelvin)
534.00
General information
Molecular weight
147.13g/mol
Molar mass
147.1430g/mol
Density
1.4258g/cm3
Appearence

1H-indole-2,3-diol, also known as isatin, appears as yellow to orange-red crystals. They are often powdered for chemical studies and are sensitive to light, leading to color changes over time.

Comment on solubility

Solubility of 1H-indole-2,3-diol

The solubility of 1H-indole-2,3-diol, a compound known for its intriguing chemical structure, can be examined through several key factors:

  • Polarity: The presence of hydroxyl (-OH) groups in its structure increases polarity, which typically enhances its solubility in polar solvents such as water.
  • Solvent Compatibility: 1H-indole-2,3-diol is more soluble in organic solvents, including alcohols and dimethyl sulfoxide (DMSO), compared to non-polar solvents like hexane.
  • Hydrogen Bonding: The ability to form hydrogen bonds contributes positively to its solubility in polar solvents. The hydrogen bond formation facilitates interaction with solvent molecules.
  • Temperature Dependency: Like many compounds, its solubility may increase with temperature, allowing for better dissolution in various media at elevated temperatures.

It's important to note that while 1H-indole-2,3-diol displays decent solubility in aqueous solutions, the exact solubility can vary based on environmental conditions and purity. As quoted from research studies, "under specific conditions, this compound illustrates a significant capacity for solubility that extends beyond basic expectations."

Overall, understanding the solubility characteristics of 1H-indole-2,3-diol is essential for its applications in medicinal chemistry and materials science.

Interesting facts

Interesting Facts about 1H-Indole-2,3-diol

1H-Indole-2,3-diol is a fascinating compound that has garnered attention in various fields of research due to its unique structural features and potential applications. Here are some noteworthy aspects:

  • Structural Significance: The indole ring system is a vital component in many biological molecules. This compound showcases a structural framework that is fundamental in numerous natural products.
  • Biological Activity: 1H-Indole-2,3-diol exhibits intriguing biological properties, including potential antioxidant effects. Its relationship with other indole derivatives makes it a compound of interest in medicinal chemistry.
  • Applications in Research: It has been studied for its effectiveness in various biochemical pathways, particularly in relation to neuronal health and cancer research. Researchers are fascinated by its potential role in modulating signal transduction pathways.
  • Natural Occurrence: This compound is found in several natural sources, suggesting its importance in ecological systems. Notable occurrences include specific fungi and plant species, adding to its intrigue in the field of phytochemistry.
  • Environmental Implications: In recent studies, the impact of indole derivatives, including 1H-indole-2,3-diol, on the environment has been assessed, particularly regarding their role in soil health and microbial interactions.

In conclusion, 1H-indole-2,3-diol is not just a simple chemical entity; its unique properties and vast potential applications make it a remarkable subject of study for chemists and biologists alike. As research continues to unfold, we may discover even more about this intriguing compound, leading to innovative applications and advances in science.

Synonyms
1H-indole-2,3-diol
2,3-Dihydroxyindole
Dioxindol
INDOLE-2,3-DIOL
CHEBI:17828
DTXSID10204936
DTXCID40127427
5638-85-7
2,3-dihydroxyindol
C02775
SCHEMBL49099
AKOS006277101
Q27102651