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2-Hydroxypyridine

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Identification
Molecular formula
C5H5NO
CAS number
142-08-5
IUPAC name
1H-pyridin-2-one
State
State

At room temperature, 2-Hydroxypyridine is in a solid state, typically stable under normal conditions.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.00
Boiling point (Celsius)
241.00
Boiling point (Kelvin)
514.00
General information
Molecular weight
95.10g/mol
Molar mass
95.0990g/mol
Density
1.2460g/cm3
Appearence

2-Hydroxypyridine typically appears as a colorless to pale yellow crystalline solid. It may also be observed as a crystalline powder.

Comment on solubility

Solubility of 1H-pyridin-2-one

1H-pyridin-2-one, commonly known as 2-pyridone, exhibits interesting solubility properties which can vary significantly depending on the solvent used. Here are some key points regarding its solubility:

  • Water Solubility: 1H-pyridin-2-one is partially soluble in water, which can be attributed to its ability to form hydrogen bonds with water molecules. However, the solubility may be limited due to the hydrophobic pyridine ring.
  • Organic Solvents: This compound is generally more soluble in organic solvents, such as ethanol and dimethyl sulfoxide (DMSO), making it suitable for various applications in organic synthesis.
  • pH Dependence: The solubility of 1H-pyridin-2-one can also be affected by the pH of the solution. In acidic environments, it may exist predominantly in its protonated form, potentially increasing solubility in certain conditions.
  • Temperature Influence: Similar to many organic compounds, an increase in temperature generally enhances the solubility of 1H-pyridin-2-one in both water and organic solvents.

In summary, the solubility of 1H-pyridin-2-one showcases the compound’s versatility, influenced by factors such as solvent type, pH, and temperature. This makes it an intriguing compound for both research and practical applications.

Interesting facts

Exploring 1H-pyridin-2-one: A Versatile Compound

1H-pyridin-2-one, also known as 2-hydroxypyridine, is an intriguing compound with a variety of applications in both academic and industrial fields. Here are some notable facts about this fascinating molecule:

  • Biological Importance: 1H-pyridin-2-one plays a significant role in medicinal chemistry. Its derivatives have been studied for their potential anti-inflammatory and anticancer properties, making it a target for drug discovery.
  • Chelating Agent: The compound exhibits the ability to form stable complexes with metal ions, which is useful in various fields such as agriculture to enhance nutrient uptake in plants and in analytical chemistry for the detection of metals.
  • Solvent Applications: Due to its polar nature, 1H-pyridin-2-one is often utilized as a solvent for reactions or as a medium in electrochemistry, enhancing the solubility of reactants and improving reaction outcomes.
  • Foundation for Synthesis: It serves as a foundational building block for synthesizing more complex organic compounds, including pharmaceuticals and agrochemicals. The versatility of its structure allows chemists to easily modify it for various applications.

In the words of renowned chemists, "The study of pyridine derivatives opens doors to a plethora of biological and industrial innovations." This emphasizes the compound's significance in ongoing research and development.

Overall, 1H-pyridin-2-one stands as a testament to the intricate interplay between structure and function in chemical compounds, highlighting its essential role in advancing not just chemistry but also various related disciplines.

Synonyms
2-HYDROXYPYRIDINE
Pyridin-2-ol
142-08-5
2-Pyridinol
2-Pyridone
72762-00-6
pyridin-2(1H)-one
2(1H)-Pyridinone
1H-pyridin-2-one
Pyridinone
2-Pyridinone
2(1H)-Pyridone
alpha-Pyridone
2-Oxopyridine
pyridin-2-one
Pyridone-2
2-hydroxy pyridine
2(lH)-Pyridinone
Pyridone-2 [French]
.alpha.-Pyridone
Pyridinol
CHEBI:16540
2-Pyridol
EINECS 205-520-3
NSC 172522
DTXSID2051716
1-Hydroxy-2-pyridine
AI3-19236
EINECS 276-824-1
1~{H}-pyridin-2-one
CHEMBL662
6770O3A2I5
NSC-172522
HYDROXYPYRIDINE, 2-
SR-1C9
DTXCID2030271
MFCD00006268
NSC172522
LEVETIRACETAM IMPURITY C [EP IMPURITY]
Levetiracetam Impurity C
66396-89-2
Hydroxypyridine
LEVETIRACETAM IMPURITY C (EP IMPURITY)
1,2-dihydropyridin-2-one
pyrdinone
LEVETIRACETAM IMPURITY, PYRIDIN-2-OL-(USP IMPURITY)
LEVETIRACETAM IMPURITY, PYRIDIN-2-OL-[USP IMPURITY]
alphaPyridone
hydroxylpyridine
2pyridinone
2pyridinol
2pyridone
2Oxopyridine
alpha -pyridone
hydroxy-pyridine
Pyridone2
pyridinyl alcohol
2-hyroxypyridine
UNII-6770O3A2I5
2-hydroxypryidine
2(lH)Pyridinone
2-Hydroxypyridine (2-Pyridinol)
lH-2-pyridone
pyrid-2-one
Pyridin-2-ol; Levetiracetam Imp. C (EP); 2-Hydroxypyridine; Levetiracetam Impurity C
2-pyridyl alcohol
2(1h)pyridone
2-hydroxy-pyridine
HRZ
T5Y
(1H)-pyridone
2-hydroxyl pyridine
pyridin2(1h)-one
1H-2-Pyridone
2H-pyridin-2-one
MFCD00462283
2-(1H)-pyridone
1-H-pyridin-2-one
pyridine, 2-hydroxy-
pyridin-2 (1h)-one
1,2-dihydro-oxopyridine
930-70-1
2(1H)-Pyridone, dimer
2-Hydroxypyridine, 97%
pyridine, 1,2-dihydro-2-oxo-
2-Pyridinol (ACD/Name 4.0)
Tox21_303883
BBL027571
BDBM50538683
NSC176167
s6360
STL146648
2-Hydroxypyridine, analytical standard
AKOS000119122
AKOS016352898
FH07796
NSC-176167
SB52270
SB52273
NCGC00357141-01
CAS-142-08-5
PD144419
DB-015956
DS-003023
H0330
NS00021648
EN300-21469
2-Hydroxypyridine, purum, >=97.0% (HPLC)
C02502
D87632
P20525
A837610
AC-907/25014059
AC-907/25014345
AC-907/25014389
Q209474
F1995-0210
Z1245646663
LEVETIRACETAM IMPURITY, PYRIDIN-2-OL- [USP IMPURITY]
B910DA2F-8676-4873-9F5A-7A9091749198
Levetiracetam impurity C, European Pharmacopoeia (EP) Reference Standard
205-520-3
276-824-1