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4-Pyridone

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Identification
Molecular formula
C5H5NO
CAS number
694-59-7
IUPAC name
1H-pyridin-4-one
State
State

At room temperature, 4-pyridone is in a solid state. It can be dissolved in water due to its polar nature.

Melting point (Celsius)
58.50
Melting point (Kelvin)
331.65
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
95.08g/mol
Molar mass
95.0840g/mol
Density
1.2870g/cm3
Appearence

4-Pyridone typically appears as a colorless to pale yellow crystalline solid. It has a characteristic odor and is often used in chemical synthesis and research.

Comment on solubility

Solubility of 1H-pyridin-4-one

1H-pyridin-4-one, a member of the pyridine family, exhibits interesting solubility characteristics that can be categorized based on various solvents. Understanding its solubility can be crucial for applications in pharmaceuticals and chemical synthesis.

Solubility in Different Solvents

  • Water: 1H-pyridin-4-one has moderate solubility in water. This solubility is attributed to the presence of the carbonyl group, which can engage in hydrogen bonding with water molecules.
  • Organic Solvents: It shows good solubility in a range of organic solvents such as ethanol, methanol, and acetone. The nonpolar characteristics of these solvents allow for effective dissolution of the compound.
  • Aromatic Solvents: The solubility increases significantly in aromatic solvents like benzene and toluene due to π-π interactions with the aromatic rings.

In summary, the solubility of 1H-pyridin-4-one is influenced by its functional groups and the nature of the solvent. As a rule of thumb, "like dissolves like," meaning polar solvents are more effective at dissolving polar compounds such as 1H-pyridin-4-one. Consider conducting empirical tests to verify solubility in specific conditions, as factors such as temperature and pH can substantially affect these properties.

Interesting facts

Interesting Facts about 1H-pyridin-4-one

1H-pyridin-4-one, often recognized for its intriguing chemical structure, is a compound that belongs to the class of heterocyclic organic compounds known as pyridines. This compound is characterized by a nitrogen atom within a six-membered aromatic ring, contributing to its unique properties and reactivity.

Key Points of Interest:

  • Biological Importance: 1H-pyridin-4-one is notable for its biological activity. It has been studied for its potential roles in pharmaceuticals, particularly as a precursor or intermediate in the synthesis of various biologically active compounds.
  • Ligand Properties: The compound is recognized for its ability to act as a ligand in coordination chemistry, forming stable complexes with transition metals. This characteristic is highly valuable in catalysis and materials science.
  • Synthesis Routes: Researchers have developed several synthetic pathways to obtain 1H-pyridin-4-one, leveraging reactions such as cyclization and oxidation. These methods highlight the compound's synthetic versatility.
  • Potential Applications: Beyond its role in medicinal chemistry, 1H-pyridin-4-one is being explored in materials science, particularly in the development of polymers and organic electronic components.
  • Derivatives: The variations and derivatives of this compound can lead to compounds with enhanced activities, making it a subject of continued research in various fields, including biochemistry and organic synthesis.

As chemists delve deeper into understanding 1H-pyridin-4-one, the compound continues to unveil its hidden potential, offering new opportunities for innovation in various scientific disciplines. It's a perfect example of how a simple structure can have profound effects across biochemistry and materials science.

Synonyms
4-HYDROXYPYRIDINE
626-64-2
pyridin-4-ol
4-Pyridinol
108-96-3
4(1H)-Pyridinone
4-Pyridone
4-Oxopyridine
4-Pyridol
gamma-Pyridone
gamma-Hydroxypyridine
4(1H)-Pyridone
.gamma.-Pyridone
.gamma.-Hydroxypyridine
NSC 5080
Pyridin-4-one
EINECS 210-958-3
BRN 0105800
DTXSID2052310
AI3-61970
3P2MV07G53
NSC-5080
EINECS 203-633-2
NSC 146174
NSC-146174
HYDROXYPYRIDINE, 4-
DTXCID9030882
CHEBI:87614
CHEBI:133125
5-21-07-00152 (Beilstein Handbook Reference)
NSC-26021
4pyridinol
gammaHydroxypyridine
4(1H)-Pyridone (8CI)
203-633-2
pyridin-4(1H)-one
1H-pyridin-4-one
4-Pyridinone
MFCD00040458
1,4-Dihydro-4-pyridinone
NSC5080
MFCD00006419
4pyridone
3454-03-3
UNII-3P2MV07G53
4-hydroxypridine
p-Hydroxypyridine
4-hydroxy-pyridine
CQG
pyridine, 4-hydroxy-
4-HYDROXYPYRIDINE (4-PYRIDINOL)
4-Hydroxypyridine, 95%
1,4-dihydropyridin-4-one
MLS004491722
4-hydroxypyridine, AldrichCPR
CHEMBL237459
SR-1C7
BCP08909
STR01041
EINECS 222-380-9
Tox21_303817
BBL022970
c1201
NSC146174
STL363251
AKOS000121024
AKOS022377006
AC-2927
BS-3730
CS-W007690
FH02024
HY-W007690
PB17041
SB52275
NCGC00357095-01
CAS-626-64-2
SMR003288679
SY003367
SY112252
DB-014976
DB-040853
CS-0166783
H0332
NS00022560
EN300-21574
D82355
AC-907/34116018
Q230024
Butanoic acid,heptafluoro-,1,10-decanediyl ester(9ci)
4-Pyridinol; 4-Pyridol; NSC 5080; gamma-Hydroxypyridine;
A1E9A648-09AC-4FC9-A7AF-37534D102469
InChI=1/C5H5NO/c7-5-1-3-6-4-2-5/h1-4H,(H,6,7