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Pyrimidone

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Identification
Molecular formula
C4H4N2O
CAS number
1193-24-4
IUPAC name
1H-pyrimidin-6-one
State
State

At room temperature, Pyrimidone is in the solid state.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.15
Boiling point (Celsius)
404.00
Boiling point (Kelvin)
677.15
General information
Molecular weight
96.08g/mol
Molar mass
96.0840g/mol
Density
1.3210g/cm3
Appearence

Pyrimidone typically appears as a white crystalline solid. Its crystals are needle-like, and it tends to absorb moisture from the air as it is hygroscopic.

Comment on solubility

Solubility of 1H-pyrimidin-6-one

When examining the solubility of 1H-pyrimidin-6-one (C4H4N2O), we find some intriguing characteristics that highlight its behavior in various solvents.

Key Points on Solubility:

  • Polar Solvents: 1H-pyrimidin-6-one is expected to be soluble in polar solvents due to its ability to form hydrogen bonds, primarily driven by the carbonyl (C=O) and nitrogen (N) groups present in the structure.
  • Non-Polar Solvents: In contrast, its solubility in non-polar solvents is likely to be very limited because the molecule's polar characteristics do not favor interactions with non-polar environments.
  • Hydrogen Bonding: The presence of functional groups that can participate in hydrogen bonding enhances its solubility in water, making it relatively soluble in aqueous solutions.

Overall, while 1H-pyrimidin-6-one demonstrates appreciable solubility in polar solvents, particularly water, understanding its solubility profile is crucial for predicting its behavior in various chemical reactions and processes.

Interesting facts

Interesting Facts about 1H-pyrimidin-6-one

1H-pyrimidin-6-one is a fascinating compound that belongs to the pyrimidine family of heterocyclic compounds, which are characterized by a six-membered ring containing nitrogen atoms. Here are some intriguing aspects of this compound:

  • Biologically Significant: Pyrimidine derivatives, including 1H-pyrimidin-6-one, are essential building blocks in biological systems. They play a crucial role in the synthesis of nucleic acids, which are fundamental for cellular function and heredity.
  • Pharmaceutical Relevance: Compounds related to 1H-pyrimidin-6-one have been explored for their pharmacological properties. Many pyrimidines have been found to exhibit anti-cancer, anti-viral, and anti-inflammatory activities, making them significant in drug discovery.
  • Versatile Synthesis: The synthesis of 1H-pyrimidin-6-one can be achieved through various methods, including cyclization and condensation reactions. This versatility in synthesis allows for the development of tailored derivatives for specific applications.
  • Intriguing Structure: The presence of a carbonyl group adjacent to the nitrogen in the ring imparts unique electronic properties. These characteristics can affect the reactivity and interaction of the compound with other molecules, providing a rich area for research.
  • Research Potential: Due to their unique structures and properties, pyrimidine compounds like 1H-pyrimidin-6-one continue to be a hot topic in current chemical research, particularly in the fields of medicinal chemistry and materials science.

In conclusion, 1H-pyrimidin-6-one not only represents a simple heterocyclic compound but also embodies a rich tapestry of scientific inquiry and potential applications. As research continues to unveil its secrets, the compound remains a noteworthy subject for chemists and biochemists alike.

Synonyms
4-Hydroxypyrimidine
4-Pyrimidinol
4562-27-0
4(3H)-Pyrimidinone
51953-17-4
4-Pyrimidinone
4-Pyrimidone
4(1H)-PYRIMIDINONE
4-Oxopyrimidine
Deaminoisocytosine
4-Oxypyrimidine
6-Hydroxypyrimidine
1H-Pyrimidin-4-one
4-Pyrimidinol (VAN)
NSC 1575
NSC 157911
EINECS 224-932-4
K43V90OY4L
AI3-52024
NSC-1575
NSC-157911
DTXSID5063524
4oxopyrimidine
4pyrimidone
4Oxypyrimidine
4Pyrimidinone
4Pyrimidinol
1HPyrimidin4one
3HPyrimidin4one
6hydroxypyrimidine
4(3h)pyrimidinone
4(1H)Pyrimidinone
4Pyrimidinol (VAN)
4-OH-P
DTXCID2040442
DTXSID80966276
pyrimidin-4-ol
51953-18-5
pyrimidin-4(3H)-one
4(3H)-Pyrimidone
pyrimidin-4(1H)-one
542-27-8
1H-pyrimidin-6-one
3H-Pyrimidin-4-one
3,4-dihydropyrimidin-4-one
pyrimidin-4-one
MFCD00038024
MFCD00006664
Uraeil
UNII-K43V90OY4L
4-hydroxy-pyrimidine
4(3H-Pyrimidone)
4-(lH)-pyrimidinone
pyrimidine-4(3h)-one
Pyrimidine, 4-hydroxy-
NSC1575
4(3H)-Pyrimidinone, >=98%
BCP04213
BCP13987
BCP26608
AC-943
AC8519
MFCD00167178
NSC157911
STK409564
STL185515
AKOS001448755
AKOS009157155
AKOS015892532
AC-2727
FP57999
GS-5924
PB32093
SB10165
AC-25243
DA-42222
SY002707
SY046617
4(3H)-Pyrimidinone, >=98.0% (NT)
DB-051325
DB-298939
CS-0019949
H1000
NS00049364
EN300-67372
O12062
AB00171795-03
AC-907/30002018
AC-907/34115014
A1-00389
Q17572767
F3329-0407
Z314605438
4-Hydroxypyrimidine pound>>4-Pyrimidinol pound>>4(3)-Pyrimidone
InChI=1/C4H4N2O/c7-4-1-2-5-3-6-4/h1-3H,(H,5,6,7