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Pyrrole-2-carboxylic acid

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Identification
Molecular formula
C5H5NO2
CAS number
634-97-9
IUPAC name
1H-pyrrole-2-carboxylic acid
State
State

At room temperature, pyrrole-2-carboxylic acid is a solid. Its crystalline form is stable under standard conditions, although it is hygroscopic and must be stored properly to avoid moisture uptake.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
296.00
Boiling point (Kelvin)
569.15
General information
Molecular weight
111.10g/mol
Molar mass
111.1010g/mol
Density
1.5150g/cm3
Appearence

Pyrrole-2-carboxylic acid typically appears as an off-white to yellow crystalline solid. It is known for its hygroscopic nature, meaning it can absorb moisture from the environment.

Comment on solubility

Solubility of 1H-pyrrole-2-carboxylic acid

1H-pyrrole-2-carboxylic acid, known for its involvement in various biochemical processes, exhibits interesting solubility characteristics:

  • Polarity: Due to the presence of both a carboxylic acid group and an aromatic pyrrole ring, this compound is relatively polar.
  • Aqueous Solubility: It is generally soluble in water, owing to the ability of the carboxylic acid group to form hydrogen bonds with water molecules.
  • Organic Solvents: It also shows solubility in various organic solvents like ethanol and methanol, enhancing its versatility in chemical applications.

To sum up, 1H-pyrrole-2-carboxylic acid is a soluble compound in both aqueous and organic solvents, making it useful for a variety of chemical syntheses and biological contexts. As with many organic compounds, the specific solubility can be influenced by temperature and concentration.

Interesting facts

Interesting Facts about 1H-Pyrrole-2-carboxylic Acid

1H-Pyrrole-2-carboxylic acid is an intriguing compound that showcases the diverse chemistry of pyrrole derivatives. Pyrroles are five-membered aromatic heterocycles that contain nitrogen, and their functionalization leads to a wealth of biochemical and synthetic applications.

Key Characteristics

  • Biological Significance: This compound is a key building block in the synthesis of various naturally occurring compounds, many of which play vital roles in biological systems.
  • Synthetic Versatility: 1H-Pyrrole-2-carboxylic acid is often utilized in organic synthesis due to its ability to undergo multiple reactions, including cyclization and functionalization, making it a valuable starting material.
  • Pharmaceutical Potential: Compounds related to 1H-pyrrole-2-carboxylic acid have shown promise in pharmacological studies, demonstrating anti-inflammatory and antimicrobial properties.

Importance in Research

This compound serves as a critical interest in the field of medicinal chemistry and drug design. It has been employed in various studies aimed at developing novel therapeutic agents due to its unique chemical structure. Researchers have noted that:

  • The carboxylic acid group enhances the compound's reactivity towards other molecules.
  • The nitrogen atom in the pyrrole ring contributes to the compound's inherent basicity, which is vital for its interaction with biological targets.

Quote from the Field

As one prominent chemist noted, "The beauty of pyrrole derivatives lies in their ability to bridge the gap between simple organic compounds and complex biological systems." This statement underscores the importance of 1H-pyrrole-2-carboxylic acid in both synthetic and natural processes.

In conclusion, 1H-pyrrole-2-carboxylic acid exemplifies the incredible potential of organic compounds. Its unique structure and reactivity continue to inspire chemists and biologists alike, pushing the boundaries of what is possible in material science and pharmaceuticals.

Synonyms
PYRROLE-2-CARBOXYLIC ACID
634-97-9
1H-Pyrrole-2-carboxylic acid
Minaline
2-Pyrrolecarboxylic acid
Minalin
CHEBI:36751
EINECS 211-221-9
NSC 48130
NSC-48130
DTXSID50212813
1H-Pyrrole-2-carboxylic acid (9CI)
DTXCID80135304
211-221-9
Pyrrole-2-carboxylicacid
Pyrrole-2-carboxylate
MFCD00005219
2NNB85QQT9
CHEMBL509027
1H-Pyrrolecarboxylic acid
PYC
Mialine
2-Minaline
Pyrrole-2-carboxylic Acid; 2-Mialine; 2-Minaline; Minalin; Minaline; NSC 48130
Pyrrole 2-carboxylate
pyrrole, 2-carboxy-
Pyrrol-2-carboxylic acid
Pyrrole 2-carboxylic acid
1H-pyrrole-carboxylic acid
UNII-2NNB85QQT9
SCHEMBL28298
SCHEMBL14725915
Pyrrole-2-carboxylic acid, 99%
BCP29322
NSC48130
STR04784
BDBM50260723
s5832
STL164370
AKOS001132829
AC-6174
CS-W001963
DB02543
FG-0411
HY-W001963
PB47384
SY014890
Minaline pound>>Pyrrole-2-carboxylicacid
DB-011234
NS00014916
P1270
Pyrrole-2-carboxylic acid, Streptomyces sp.
EN300-13984
C05942
AC-907/25014066
Q27104383
Z94599900
F8880-6911
98C22043-F536-4DC6-8C61-12A0C5E6A5D6