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Pyrrolo[3,2-b]pyridine

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Identification
Molecular formula
C8H6N2
CAS number
274-37-5
IUPAC name
1H-pyrrolo[3,2-b]pyridine
State
State

At room temperature, pyrrolo[3,2-b]pyridine is generally found in a solid state, observed as crystalline powder. Its stability and physical form make it suitable for various analytical and chemical processes in laboratory settings.

Melting point (Celsius)
48.00
Melting point (Kelvin)
321.15
Boiling point (Celsius)
249.00
Boiling point (Kelvin)
522.15
General information
Molecular weight
118.14g/mol
Molar mass
118.1340g/mol
Density
1.1677g/cm3
Appearence

Pyrrolo[3,2-b]pyridine is typically characterized as a white to off-white crystalline powder. It may vary slightly in shade and granularity depending on the specific form or purity of the compound prepared.

Comment on solubility

Solubility of 1H-pyrrolo[3,2-b]pyridine

1H-pyrrolo[3,2-b]pyridine is a fascinating compound with interesting solubility characteristics. Understanding its solubility can provide insights into its reactivity, use in synthesis, and potential applications. The solubility of this compound can be characterized as follows:

  • Polar vs. Non-Polar Solvents: 1H-pyrrolo[3,2-b]pyridine tends to be soluble in polar organic solvents such as ethanol and dichloromethane, while exhibiting lower solubility in non-polar solvents like hexane.
  • Temperature Dependence: The solubility often increases with rising temperature; thus, it is more soluble at elevated temperatures, allowing for greater dissolution in mixed solvent systems.
  • pH Influence: The solubility may be affected by the pH of the solution; alterations in pH can lead to protonation or deprotonation of functional groups, changing the compound's solubility profile.
  • Hydrogen Bonding: The nitrogen atoms in the pyrrolic structure can engage in hydrogen bonding, enhancing solubility in certain polar solvents through interactions with solvent molecules.

In conclusion, while 1H-pyrrolo[3,2-b]pyridine may not be soluble in all solvents, it demonstrates noteworthy solubility in specific conditions. Thus, when sourcing this compound for experimentation or industrial processes, one must consider the appropriate solvent systems to maximize its solubility.

Interesting facts

Interesting Facts about 1H-pyrrolo[3,2-b]pyridine

1H-pyrrolo[3,2-b]pyridine is a fascinating heterocyclic compound that exhibits a unique structure and remarkable properties. Here are some insights into this intriguing molecule:

  • Structural Characteristics: The compound features a bicyclic arrangement, incorporating both a pyrrole and a pyridine ring. This duality contributes to its diverse reactivity and the potential for various derivative formations.
  • Biological Relevance: Compounds like 1H-pyrrolo[3,2-b]pyridine have been studied for their potential biological activities. They can serve as lead compounds in drug discovery, particularly in the development of substances targeting neurological disorders and various cancers.
  • Synthetic Pathways: The synthesis of 1H-pyrrolo[3,2-b]pyridine can employ several approaches, including cyclization reactions and functionalization of existing pyridine derivatives. This versatility makes it a point of interest among synthetic chemists.
  • Applications: Besides its pharmacological potential, this compound is also used in the design of organic semiconductors and materials for electronics, illustrating its significance beyond just organic chemistry.
  • Research Trends: Ongoing research is investigating the compound's role in catalysis and its effectiveness in various organic transformations, emphasizing its importance in the field of organic synthesis.

As a student or researcher in chemistry, exploring the structure and applications of 1H-pyrrolo[3,2-b]pyridine offers exciting opportunities to dive into the world of organic compounds with significant real-world relevance.

Synonyms
4-AZAINDOLE
272-49-1
1H-pyrrolo[3,2-b]pyridine
1,4-Diazaindene
1H-Pyrrolo(3,2-b)pyridine
PYRROLOPYRIDINE
1H-Pyrrolo[3.2-b]pyridine
MFCD00971977
BRN 0109683
4-Azaindole;4-Azaindole
DTXSID00181666
5-23-06-00303 (Beilstein Handbook Reference)
pyrrolo[3,2-b]pyridine
SCHEMBL12565
CHEMBL5184883
SCHEMBL16662494
SCHEMBL17850816
DTXCID40104157
XWIYUCRMWCHYJR-UHFFFAOYSA-N
ALBB-037846
BCP26719
CS-D1166
AC-088
BBL103666
STL557476
AKOS005256883
FA16127
PB18523
PS-4925
1H-pyrrolo[3,2-b]pyridine, AldrichCPR
HY-20362
SY019307
DB-016054
P2041
EN300-94605
Q27454752
Z1925930568
4JP
674-574-1